Molecular reactivity profiling upon immunotherapy with a 300 IR sublingual house dust mite tablet reveals marked humoral changes towards major allergens

Background Molecular antibody reactivity profiles have not yet been studied in depth in patients treated by sublingual house dust mite (HDM) tablet immunotherapy. Humoral immune responses to a large panel of HDM mite allergens were studied using allergen microarray technology in a subset of clinical...

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Published in:Allergy (Copenhagen) 2022-10, Vol.77 (10), p.3084-3095
Main Authors: Potapova, Ekaterina, Bordas‐Le Floch, Véronique, Schlederer, Thomas, Vrtala, Susanne, Huang, Huey‐Jy, Canonica, Giorgio W., Valenta, Rudolf, Matricardi, Paolo M., Mascarell, Laurent
Format: Article
Language:English
Subjects:
allergen microarray
Allergens
allergen‐specific immunotherapy
Allergies
Animals
Antigens, Dermatophagoides
Asthma
Asthma - therapy
Der p 1 antigen
house dust mite allergy
Humans
Immune response (humoral)
Immunoglobulin E
Immunoglobulin G
Immunologic Factors
Immunotherapy
molecular reactivity profile
Oral administration
Patients
Population studies
Pyridinolcarbamate
Pyroglyphidae
Serum levels
SLIT tablet
Sublingual Immunotherapy
Tablets
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Summary:Background Molecular antibody reactivity profiles have not yet been studied in depth in patients treated by sublingual house dust mite (HDM) tablet immunotherapy. Humoral immune responses to a large panel of HDM mite allergens were studied using allergen microarray technology in a subset of clinically defined high and low responder patients from a double‐blind placebo‐controlled allergen‐specific immunotherapy (AIT) trial using sublingual 300 IR HDM tablets. Methods Serum levels of IgE, IgG and IgG4 to 13 Dermatophagoides pteronyssinus molecules were measured at baseline and after 1‐year AIT, using allergen microarrays in 100 subjects exhibiting high or low clinical benefit. Results Der p 1, Der p 2 and Der p 23 were the most frequently recognized allergens in the study population. Patients with HDM‐related asthma had significantly higher allergen‐specific IgE levels to Der p 1 and Der p 23. No significant difference in the distribution of allergen sensitization pattern was observed between high and low responders. An increase in serum allergen‐specific IgG and IgG4 occurred upon AIT, in particular to allergens Der p 1, Der p 2 and Der p 23 (p 
ISSN:0105-4538
1398-9995
DOI:10.1111/all.15327