Exploiting a strong coupling regime of organic pentamer surface plasmon resonance based on the Otto configuration for creatinine detection

The sandwiched material-analyte layer in the surface plasmon resonance (SPR)-Otto configuration emulates an optical cavity and, coupled with large optical nonlinearity material, the rate of light escaping from the system is reduced, allowing the formation of a strong coupling regime. Here, we report...

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Bibliographic Details
Published in:Optics express 2022-04, Vol.30 (9), p.14478-14491
Main Authors: Ahmad Khushaini, Muhammad Asif, Azeman, Nur Hidayah, Mat Salleh, Muhamad, Tg Abdul Aziz, Tg Hasnan, A Bakar, Ahmad Ashrif, De La Rue, Richard M, Md Zain, Ahmad Rifqi
Format: Article
Language:English
Subjects:
Creatinine
Surface Plasmon Resonance - methods
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Summary:The sandwiched material-analyte layer in the surface plasmon resonance (SPR)-Otto configuration emulates an optical cavity and, coupled with large optical nonlinearity material, the rate of light escaping from the system is reduced, allowing the formation of a strong coupling regime. Here, we report an organic pentamer SPR sensor using the Otto configuration to induce a strong coupling regime for creatinine detection. Prior to that, the SPR sensor chip was modified with an organic pentamer, 1,4-bis[2-(5-thiophene-2-yl)-1-benzothiopene]-2,5-dioctyloxybenzene (BOBzBT ). To improve the experimental calibration curve, a normalisation approach based on the strong coupling-induced second dip was also developed. By using this procedure, the performance of the sensor improved to 0.11 mg/dL and 0.36 mg/dL for the detection and quantification limits, respectively.
ISSN:1094-4087
1094-4087
DOI:10.1364/OE.448947