Template-Free Synthesis of Porous Fluorescent Carbon Nanomaterials with Gluten for Intracellular Imaging and Drug Delivery

A series of carbon nanomaterials, including carbon dots, carbon nanorings (CNRs), and porous carbon nanoballs, were facilely prepared by a template-free hydrothermal treatment of gluten as the sole carbon source. Driven by the hydrophobicity interaction, a concentration-dependent self-assembly of gl...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2022-05, Vol.14 (18), p.21310-21318
Main Authors: Xu, Yalan, Wang, Chan, Wu, Tao, Ran, Guoxia, Song, Qijun
Format: Article
Language:English
Subjects:
Carbon
Doxorubicin - pharmacology
Drug Carriers
Drug Delivery Systems - methods
Functional Nanostructured Materials (including low-D carbon)
Glutens
Nanostructures
Porosity
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Summary:A series of carbon nanomaterials, including carbon dots, carbon nanorings (CNRs), and porous carbon nanoballs, were facilely prepared by a template-free hydrothermal treatment of gluten as the sole carbon source. Driven by the hydrophobicity interaction, a concentration-dependent self-assembly of gluten was observed in an aqueous solution, leading to the subsequent formation of different morphologies of carbon nanomaterials in a hydrothermal treatment. Among these carbon nanomaterials, the CNRs exhibit bright photoluminescence with a quantum yield of 47.0%. Furthermore, CNRs also have a large surface area and low toxicity, making them an excellent drug carrier for chemotherapeutics. A model drug molecule doxorubicin (DOX) was successfully loaded on the CNRs, and the CNRs-DOX complexes exhibit a pH-dependent DOX release behavior. Compared with free DOX, the CNRs-DOX complexes can induce a higher level of apoptosis and lower level of necrosis, showing promise as anticancer agents.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.2c00941