Copper()-catalyzed radical carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform: synthesis of-β-lactams

A novel Cu(CH 3 CN) 4 PF 6 -catalyzed carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform to afford 4-(2,2,2-trichloroethyl)-β-lactams is described. The reaction proceeded at 110 °C in air with di- t -butyl peroxide. Preliminary studies indicated that the reaction under...

Full description

Saved in:
Bibliographic Details
Published in:RSC advances 2021-08, Vol.11 (45), p.2881-2884
Main Authors: Gan, Zixu, Zhang, Ke, Shi, Peng, Zhao, Yingsheng, Zeng, Runsheng
Format: Article
Language:English
Subjects:
Aminoquinolines
Chemistry
Chloroform
Copper
Free radicals
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A novel Cu(CH 3 CN) 4 PF 6 -catalyzed carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform to afford 4-(2,2,2-trichloroethyl)-β-lactams is described. The reaction proceeded at 110 °C in air with di- t -butyl peroxide. Preliminary studies indicated that the reaction undergoes a free radical mechanism via a Cu( i )/Cu( ii )/Cu( iii ) catalytic cycle. A novel Cu(CH 3 CN) 4 PF 6 -catalyzed carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform to afford 4-(2,2,2-trichloroethyl)-β-lactams is described.
ISSN:2046-2069
2046-2069
DOI:10.1039/d1ra05233k