Gene Co-Expression Network Analysis Reveals the Correlation Patterns Among Genes in Different Temperature Stress Adaptation of Manila Clam

The Manila clam ( Ruditapes philippinarum ) is one of the most important aquaculture species and widely distributed along the coasts of China, Japan, and Korea. Due to its wide distribution, it can tolerate a wide range of temperature. Studying the gene expression profiles of clam gills had found di...

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Bibliographic Details
Published in:Marine biotechnology (New York, N.Y.) N.Y.), 2022-06, Vol.24 (3), p.542-554
Main Authors: Jahan, Kifat, Yin, Zhihui, Zhang, Yanming, Yan, Xiwu, Nie, Hongtao
Format: Article
Language:English
Subjects:
Adaptation
Apoptosis
Aquaculture
Biomedical and Life Sciences
Clams
Climate change
Connectivity
Engineering
Freshwater & Marine Ecology
Gene expression
Genes
Gills
Heat
High temperature
Life Sciences
Low temperature
Marine molluscs
Metabolism
Microbiology
Modules
Network analysis
Original Article
Ruditapes philippinarum
Temperature effects
Temperature tolerance
Transcriptomes
Zoology
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Summary:The Manila clam ( Ruditapes philippinarum ) is one of the most important aquaculture species and widely distributed along the coasts of China, Japan, and Korea. Due to its wide distribution, it can tolerate a wide range of temperature. Studying the gene expression profiles of clam gills had found differentially expressed genes (DEGs) and pathway involved in temperature stress tolerance. A systematic study of cellular response to temperature stress may provide insights into the mechanism of acquired tolerance. Here, weighted gene co-expression network analysis (WGCNA) was carried out using RNA-seq data from gill transcriptome in response to high and low temperature stress. There are a total 32 gene modules, of which 18 gene modules were identified as temperature-related modules. Blue module was one significantly correlated with temperature which was associated with cellular metabolism, apoptosis pathway, ER stress, and others.
ISSN:1436-2228
1436-2236
DOI:10.1007/s10126-022-10117-z