In situ gelling nanosuspension as an advanced platform for fluticasone propionate nasal delivery

[Display omitted] In this work we present the development of in situ gelling nanosuspension as advanced form for fluticasone propionate nasal delivery. Drug nanocrystals were prepared by wet milling technique. Incorporation of drug nanocrystals into polymeric in situ gelling system with pectin and s...

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Published in:European journal of pharmaceutics and biopharmaceutics 2022-06, Vol.175, p.27-42
Main Authors: Nižić Nodilo, Laura, Perkušić, Mirna, Ugrina, Ivo, Špoljarić, Drago, Jakobušić Brala, Cvijeta, Amidžić Klarić, Daniela, Lovrić, Jasmina, Saršon, Vesna, Safundžić Kučuk, Maša, Zadravec, Dijana, Kalogjera, Livije, Pepić, Ivan, Hafner, Anita
Format: Article
Language:English
Subjects:
3D printed nasal cavity model
Administration, Intranasal
Chronic rhinosinusitis
Fluticasone
Fluticasone propionate
Gels
In situ gelling
Nanosuspension
Nasal drug delivery
Nose
Polymers - chemistry
Viscosity
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Summary:[Display omitted] In this work we present the development of in situ gelling nanosuspension as advanced form for fluticasone propionate nasal delivery. Drug nanocrystals were prepared by wet milling technique. Incorporation of drug nanocrystals into polymeric in situ gelling system with pectin and sodium hyaluronate as constitutive polymers was fine-tuned attaining appropriate formulation surface tension, viscosity and gelling ability. Drug nanonisation improved the release profile and enhanced formulation mucoadhesive properties. QbD approach combining formulation and administration parameters resulted in optimised nasal deposition profile, with 51.8% of the dose deposited in the middle meatus, the critical region in the treatment of rhinosinusitis and nasal polyposis. Results obtained in biocompatibility and physico-chemical stability studies confirmed the leading formulation potential for safe and efficient nasal corticosteroid delivery.
ISSN:0939-6411
1873-3441
DOI:10.1016/j.ejpb.2022.04.009