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The role of raftlin in the pathogenesis of chronic rhinosinusitis with nasal polyps
Purpose The aim of this study was to investigate the possible role of raftlin (RFTN) in chronic rhinosinusitis with nasal polyps (CRSwNP). There is no study in the literature investigating the role of RFTN in the pathogenesis of CRSwNP. Methods The present study was designed as a case–control study...
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| Published in: | European archives of oto-rhino-laryngology 2022-07, Vol.279 (7), p.3519-3523 |
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| container_title | European archives of oto-rhino-laryngology |
| container_volume | 279 |
| creator | Kumbul, Yusuf Çağdaş Yasan, Hasan Okur, Erdoğan Tüz, Mustafa Sivrice, Mehmet Emre Akın, Vural Şirin, Fevziye Burcu Doğan Kıran, Eltaf |
| description | Purpose
The aim of this study was to investigate the possible role of raftlin (RFTN) in chronic rhinosinusitis with nasal polyps (CRSwNP). There is no study in the literature investigating the role of RFTN in the pathogenesis of CRSwNP.
Methods
The present study was designed as a case–control study and conducted between 25.09.2020 and 01.01.2022. CRSwNP and control groups were formed in the study. Serum and tissue samples were taken from each patient in the study and their RFTN levels were measured. While nasal polyps were used for tissue samples in the CRSwNP group, middle meatus mucosa obtained during concha bullosa surgery was used in the control group.
Results
The control group included 31 patients (8 female, 23 male) and the CRSwNP group included 49 patients (14 female, 35 male). The mean age of the control group was 40.42 ± 9.99 years, while the mean age of the CRSwNP group was 43.47 ± 10.19 years. When the groups are compared in terms of gender and age, there were no statistically significant differences (
p
= 0.78,
p
= 0.19, respectively). The serum RFTN levels in the control and CRSwNP groups were 7.85 ± 10.87 ng/ml, and 7.02 ± 8.59 ng/ml, respectively (
p
= 0.45). The tissue RFTN levels in the control group and CRSwNP group were 87.15 ± 69.91 ng/ml, and 66.50 ± 17.10 ng/ml, respectively (
p
= 0.04, statistically significant).
Conclusion
RFTN deficiency in nasal polyp tissue may be one of the reasons for the development of CRSwNP. Further studies are needed to elucidate the role of RFTN in CRSwNP. |
| doi_str_mv | 10.1007/s00405-022-07413-8 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2658229153</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2658229153</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-c22ff46886c5c689a30c76b2a87c81975ef6977280782606cfc7390d8de8a22a3</originalsourceid><addsrcrecordid>eNp9kM9LwzAUx4Mobk7_AQ_So5fqa5Im6VGGv2DgwXkOWZauGV1SkxbZf29mp0fhwYP3_QHvg9B1AXcFAL-PABTKHDDOgdOC5OIETQtKaE45ZqdoChXhOaWcT9BFjFsAKGlFztGElFSICtgUvS8bkwXfmszXWVB131qXpenTuVN94zfGmWjjQdZN8M7qLDTW-WjdEG2flC_bN5lTUbVZ59t9Fy_RWa3aaK6Oe4Y-nh6X85d88fb8On9Y5JpQ3uca47qmTAimS81EpQhozlZYCa5FUfHS1KziHAvgAjNgutacVLAWayMUxorM0O3Y2wX_OZjYy52N2rStcsYPUWJWCoyroiTJikerDj7GYGrZBbtTYS8LkAeYcoQpE0z5A1OKFLo59g-rnVn_RX7pJQMZDTFJbmOC3PohuPTzf7XfuVN_Yg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2658229153</pqid></control><display><type>article</type><title>The role of raftlin in the pathogenesis of chronic rhinosinusitis with nasal polyps</title><source>Springer Nature</source><creator>Kumbul, Yusuf Çağdaş ; Yasan, Hasan ; Okur, Erdoğan ; Tüz, Mustafa ; Sivrice, Mehmet Emre ; Akın, Vural ; Şirin, Fevziye Burcu ; Doğan Kıran, Eltaf</creator><creatorcontrib>Kumbul, Yusuf Çağdaş ; Yasan, Hasan ; Okur, Erdoğan ; Tüz, Mustafa ; Sivrice, Mehmet Emre ; Akın, Vural ; Şirin, Fevziye Burcu ; Doğan Kıran, Eltaf</creatorcontrib><description>Purpose
The aim of this study was to investigate the possible role of raftlin (RFTN) in chronic rhinosinusitis with nasal polyps (CRSwNP). There is no study in the literature investigating the role of RFTN in the pathogenesis of CRSwNP.
Methods
The present study was designed as a case–control study and conducted between 25.09.2020 and 01.01.2022. CRSwNP and control groups were formed in the study. Serum and tissue samples were taken from each patient in the study and their RFTN levels were measured. While nasal polyps were used for tissue samples in the CRSwNP group, middle meatus mucosa obtained during concha bullosa surgery was used in the control group.
Results
The control group included 31 patients (8 female, 23 male) and the CRSwNP group included 49 patients (14 female, 35 male). The mean age of the control group was 40.42 ± 9.99 years, while the mean age of the CRSwNP group was 43.47 ± 10.19 years. When the groups are compared in terms of gender and age, there were no statistically significant differences (
p
= 0.78,
p
= 0.19, respectively). The serum RFTN levels in the control and CRSwNP groups were 7.85 ± 10.87 ng/ml, and 7.02 ± 8.59 ng/ml, respectively (
p
= 0.45). The tissue RFTN levels in the control group and CRSwNP group were 87.15 ± 69.91 ng/ml, and 66.50 ± 17.10 ng/ml, respectively (
p
= 0.04, statistically significant).
Conclusion
RFTN deficiency in nasal polyp tissue may be one of the reasons for the development of CRSwNP. Further studies are needed to elucidate the role of RFTN in CRSwNP.</description><identifier>ISSN: 0937-4477</identifier><identifier>EISSN: 1434-4726</identifier><identifier>DOI: 10.1007/s00405-022-07413-8</identifier><identifier>PMID: 35488906</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Case-Control Studies ; Chronic Disease ; Female ; Head and Neck Surgery ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nasal Polyps - complications ; Nasal Polyps - pathology ; Nasal Polyps - surgery ; Neurosurgery ; Otorhinolaryngology ; Rhinitis - complications ; Rhinitis - surgery ; Rhinology ; Sinusitis - complications ; Sinusitis - pathology ; Sinusitis - surgery</subject><ispartof>European archives of oto-rhino-laryngology, 2022-07, Vol.279 (7), p.3519-3523</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-c22ff46886c5c689a30c76b2a87c81975ef6977280782606cfc7390d8de8a22a3</citedby><cites>FETCH-LOGICAL-c347t-c22ff46886c5c689a30c76b2a87c81975ef6977280782606cfc7390d8de8a22a3</cites><orcidid>0000-0002-7680-7105 ; 0000-0002-5470-6784 ; 0000-0002-0050-4837 ; 0000-0002-2396-6794 ; 0000-0001-5304-1007 ; 0000-0003-4043-7277 ; 0000-0002-0713-2933 ; 0000-0003-4384-840X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35488906$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumbul, Yusuf Çağdaş</creatorcontrib><creatorcontrib>Yasan, Hasan</creatorcontrib><creatorcontrib>Okur, Erdoğan</creatorcontrib><creatorcontrib>Tüz, Mustafa</creatorcontrib><creatorcontrib>Sivrice, Mehmet Emre</creatorcontrib><creatorcontrib>Akın, Vural</creatorcontrib><creatorcontrib>Şirin, Fevziye Burcu</creatorcontrib><creatorcontrib>Doğan Kıran, Eltaf</creatorcontrib><title>The role of raftlin in the pathogenesis of chronic rhinosinusitis with nasal polyps</title><title>European archives of oto-rhino-laryngology</title><addtitle>Eur Arch Otorhinolaryngol</addtitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><description>Purpose
The aim of this study was to investigate the possible role of raftlin (RFTN) in chronic rhinosinusitis with nasal polyps (CRSwNP). There is no study in the literature investigating the role of RFTN in the pathogenesis of CRSwNP.
Methods
The present study was designed as a case–control study and conducted between 25.09.2020 and 01.01.2022. CRSwNP and control groups were formed in the study. Serum and tissue samples were taken from each patient in the study and their RFTN levels were measured. While nasal polyps were used for tissue samples in the CRSwNP group, middle meatus mucosa obtained during concha bullosa surgery was used in the control group.
Results
The control group included 31 patients (8 female, 23 male) and the CRSwNP group included 49 patients (14 female, 35 male). The mean age of the control group was 40.42 ± 9.99 years, while the mean age of the CRSwNP group was 43.47 ± 10.19 years. When the groups are compared in terms of gender and age, there were no statistically significant differences (
p
= 0.78,
p
= 0.19, respectively). The serum RFTN levels in the control and CRSwNP groups were 7.85 ± 10.87 ng/ml, and 7.02 ± 8.59 ng/ml, respectively (
p
= 0.45). The tissue RFTN levels in the control group and CRSwNP group were 87.15 ± 69.91 ng/ml, and 66.50 ± 17.10 ng/ml, respectively (
p
= 0.04, statistically significant).
Conclusion
RFTN deficiency in nasal polyp tissue may be one of the reasons for the development of CRSwNP. Further studies are needed to elucidate the role of RFTN in CRSwNP.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Head and Neck Surgery</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nasal Polyps - complications</subject><subject>Nasal Polyps - pathology</subject><subject>Nasal Polyps - surgery</subject><subject>Neurosurgery</subject><subject>Otorhinolaryngology</subject><subject>Rhinitis - complications</subject><subject>Rhinitis - surgery</subject><subject>Rhinology</subject><subject>Sinusitis - complications</subject><subject>Sinusitis - pathology</subject><subject>Sinusitis - surgery</subject><issn>0937-4477</issn><issn>1434-4726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kM9LwzAUx4Mobk7_AQ_So5fqa5Im6VGGv2DgwXkOWZauGV1SkxbZf29mp0fhwYP3_QHvg9B1AXcFAL-PABTKHDDOgdOC5OIETQtKaE45ZqdoChXhOaWcT9BFjFsAKGlFztGElFSICtgUvS8bkwXfmszXWVB131qXpenTuVN94zfGmWjjQdZN8M7qLDTW-WjdEG2flC_bN5lTUbVZ59t9Fy_RWa3aaK6Oe4Y-nh6X85d88fb8On9Y5JpQ3uca47qmTAimS81EpQhozlZYCa5FUfHS1KziHAvgAjNgutacVLAWayMUxorM0O3Y2wX_OZjYy52N2rStcsYPUWJWCoyroiTJikerDj7GYGrZBbtTYS8LkAeYcoQpE0z5A1OKFLo59g-rnVn_RX7pJQMZDTFJbmOC3PohuPTzf7XfuVN_Yg</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Kumbul, Yusuf Çağdaş</creator><creator>Yasan, Hasan</creator><creator>Okur, Erdoğan</creator><creator>Tüz, Mustafa</creator><creator>Sivrice, Mehmet Emre</creator><creator>Akın, Vural</creator><creator>Şirin, Fevziye Burcu</creator><creator>Doğan Kıran, Eltaf</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7680-7105</orcidid><orcidid>https://orcid.org/0000-0002-5470-6784</orcidid><orcidid>https://orcid.org/0000-0002-0050-4837</orcidid><orcidid>https://orcid.org/0000-0002-2396-6794</orcidid><orcidid>https://orcid.org/0000-0001-5304-1007</orcidid><orcidid>https://orcid.org/0000-0003-4043-7277</orcidid><orcidid>https://orcid.org/0000-0002-0713-2933</orcidid><orcidid>https://orcid.org/0000-0003-4384-840X</orcidid></search><sort><creationdate>20220701</creationdate><title>The role of raftlin in the pathogenesis of chronic rhinosinusitis with nasal polyps</title><author>Kumbul, Yusuf Çağdaş ; Yasan, Hasan ; Okur, Erdoğan ; Tüz, Mustafa ; Sivrice, Mehmet Emre ; Akın, Vural ; Şirin, Fevziye Burcu ; Doğan Kıran, Eltaf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-c22ff46886c5c689a30c76b2a87c81975ef6977280782606cfc7390d8de8a22a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Head and Neck Surgery</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nasal Polyps - complications</topic><topic>Nasal Polyps - pathology</topic><topic>Nasal Polyps - surgery</topic><topic>Neurosurgery</topic><topic>Otorhinolaryngology</topic><topic>Rhinitis - complications</topic><topic>Rhinitis - surgery</topic><topic>Rhinology</topic><topic>Sinusitis - complications</topic><topic>Sinusitis - pathology</topic><topic>Sinusitis - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumbul, Yusuf Çağdaş</creatorcontrib><creatorcontrib>Yasan, Hasan</creatorcontrib><creatorcontrib>Okur, Erdoğan</creatorcontrib><creatorcontrib>Tüz, Mustafa</creatorcontrib><creatorcontrib>Sivrice, Mehmet Emre</creatorcontrib><creatorcontrib>Akın, Vural</creatorcontrib><creatorcontrib>Şirin, Fevziye Burcu</creatorcontrib><creatorcontrib>Doğan Kıran, Eltaf</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of oto-rhino-laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumbul, Yusuf Çağdaş</au><au>Yasan, Hasan</au><au>Okur, Erdoğan</au><au>Tüz, Mustafa</au><au>Sivrice, Mehmet Emre</au><au>Akın, Vural</au><au>Şirin, Fevziye Burcu</au><au>Doğan Kıran, Eltaf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of raftlin in the pathogenesis of chronic rhinosinusitis with nasal polyps</atitle><jtitle>European archives of oto-rhino-laryngology</jtitle><stitle>Eur Arch Otorhinolaryngol</stitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>279</volume><issue>7</issue><spage>3519</spage><epage>3523</epage><pages>3519-3523</pages><issn>0937-4477</issn><eissn>1434-4726</eissn><abstract>Purpose
The aim of this study was to investigate the possible role of raftlin (RFTN) in chronic rhinosinusitis with nasal polyps (CRSwNP). There is no study in the literature investigating the role of RFTN in the pathogenesis of CRSwNP.
Methods
The present study was designed as a case–control study and conducted between 25.09.2020 and 01.01.2022. CRSwNP and control groups were formed in the study. Serum and tissue samples were taken from each patient in the study and their RFTN levels were measured. While nasal polyps were used for tissue samples in the CRSwNP group, middle meatus mucosa obtained during concha bullosa surgery was used in the control group.
Results
The control group included 31 patients (8 female, 23 male) and the CRSwNP group included 49 patients (14 female, 35 male). The mean age of the control group was 40.42 ± 9.99 years, while the mean age of the CRSwNP group was 43.47 ± 10.19 years. When the groups are compared in terms of gender and age, there were no statistically significant differences (
p
= 0.78,
p
= 0.19, respectively). The serum RFTN levels in the control and CRSwNP groups were 7.85 ± 10.87 ng/ml, and 7.02 ± 8.59 ng/ml, respectively (
p
= 0.45). The tissue RFTN levels in the control group and CRSwNP group were 87.15 ± 69.91 ng/ml, and 66.50 ± 17.10 ng/ml, respectively (
p
= 0.04, statistically significant).
Conclusion
RFTN deficiency in nasal polyp tissue may be one of the reasons for the development of CRSwNP. Further studies are needed to elucidate the role of RFTN in CRSwNP.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35488906</pmid><doi>10.1007/s00405-022-07413-8</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-7680-7105</orcidid><orcidid>https://orcid.org/0000-0002-5470-6784</orcidid><orcidid>https://orcid.org/0000-0002-0050-4837</orcidid><orcidid>https://orcid.org/0000-0002-2396-6794</orcidid><orcidid>https://orcid.org/0000-0001-5304-1007</orcidid><orcidid>https://orcid.org/0000-0003-4043-7277</orcidid><orcidid>https://orcid.org/0000-0002-0713-2933</orcidid><orcidid>https://orcid.org/0000-0003-4384-840X</orcidid></addata></record> |
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| source | Springer Nature |
| subjects | Adult Case-Control Studies Chronic Disease Female Head and Neck Surgery Humans Male Medicine Medicine & Public Health Middle Aged Nasal Polyps - complications Nasal Polyps - pathology Nasal Polyps - surgery Neurosurgery Otorhinolaryngology Rhinitis - complications Rhinitis - surgery Rhinology Sinusitis - complications Sinusitis - pathology Sinusitis - surgery |
| title | The role of raftlin in the pathogenesis of chronic rhinosinusitis with nasal polyps |
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