Effects of photobiomodulation in experimental spinal cord injury models: A systematic review

This systematic review investigated the repercussions of photobiomodulation using low‐level laser therapy (LLLT) for the treatment of spinal cord injury (SCI) in experimental models. Studies were identified from relevant databases published between January 2009 and December 2021. Nineteen original a...

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Bibliographic Details
Published in:Journal of biophotonics 2022-08, Vol.15 (8), p.e202200059-n/a
Main Authors: Cruz Tobelem, Daysi, Silva, Tamiris, Araujo, Tamires, Andreo, Lucas, Malavazzi, Tainá Caroline dos Santos, Horliana, Anna Carolina Ratto Tempestini, Fernandes, Kristianne Porta Santos, Bussadori, Sandra Kalil, Mesquita‐Ferrari, Raquel Agnelli
Format: Article
Language:English
Subjects:
Cytokines
Inflammation
Injury prevention
Irradiation
Light therapy
low level laser therapy
Neuroprotection
photobiomodulation
Recovery of function
Spinal cord injuries
spinal cord injury
Standardization
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Summary:This systematic review investigated the repercussions of photobiomodulation using low‐level laser therapy (LLLT) for the treatment of spinal cord injury (SCI) in experimental models. Studies were identified from relevant databases published between January 2009 and December 2021. Nineteen original articles were selected and 68.4% used light at an infrared wavelength. There was a considerable variation of the power used (from 25 to 200 mW), total application time (8–3000 s) and total energy (0.3–450 J). In 79% of the studies, irradiation was initiated immediately after or within 2 h of the SCI, and treatment time ranged continuously from 5 to 21 days. In conclusion, LLLT can be an auxiliary therapy in the treatment of SCI, playing a neuroprotective role, enabling functional recovery, increasing the concentration of nerve connections around the injury site and reducing pro‐inflammatory cytokines. However, there is a need for standardization in the dosimetric parameters. Spinal Cord Injury is a clinical situation of extreme social relevance, which can lead to great functional limitation, impacting the quality of life of people with this type of injury. This fact is highlighted by the scarcity of treatment possibilities to alleviate these limitations. In this context, this review brings interesting and innovative results about studies that used photobiomodulation after this type of injury in different experimental models and showed positive results for neuromuscular repair.
ISSN:1864-063X
1864-0648
DOI:10.1002/jbio.202200059