Lack of Association Between PDCD-1 Polymorphisms and Colorectal Cancer Risk: A Case-Control Study

Functional variants of immune-related genes may be implicated in the occurrence of colorectal cancer (CRC). In this study, Programmed cell death (PDCD)-1.6 (rs10204525 T/C), PDCD-1.7 (rs7421861 A/G), and PDCD-1.9 (rs2227982 A/G) loci were selected to explore gene expression and the potential suscept...

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Bibliographic Details
Published in:Immunological investigations 2022-08, Vol.51 (6), p.1867-1882
Main Authors: Lin, Jing, Chen, Hanshen, Huang, Yufang, Tang, Weifeng, Zhang, Sheng, Chen, Yu
Format: Article
Language:English
Subjects:
Colorectal cancer
PDCD-1.6
PDCD-1.7
PDCD-1.9
polymorphism
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Summary:Functional variants of immune-related genes may be implicated in the occurrence of colorectal cancer (CRC). In this study, Programmed cell death (PDCD)-1.6 (rs10204525 T/C), PDCD-1.7 (rs7421861 A/G), and PDCD-1.9 (rs2227982 A/G) loci were selected to explore gene expression and the potential susceptibility to the development of CRC. Here, 1,003 CRC patients and 1,303 controls were included and three PDCD-1 tagging loci were selected and analyzed by using SNPscan genotyping assays. SHESIS software was harnessed to obtain the haplotypes of the PDCD-1 gene. We found that the genotype and allele distribution of PDCD-1 tagging loci did not significantly affect the risk of CRC. Adjustment for body mass index, age, smoking, alcohol using and sex also found that PDCD-1 tagging loci did not influence the occurrence of CRC. In conclusion, this study suggests that the PDCD-1 tagging loci (rs10204525, rs7421861, and rs2227982) are not correlated with CRC susceptibility.
ISSN:0882-0139
1532-4311
DOI:10.1080/08820139.2022.2069504