Electroacupuncture Enhances Gastric Accommodation via the Autonomic and Cytokine Mechanisms in Functional Dyspepsia

Background Due to complex pathophysiology of functional dyspepsia, medications to treat functional dyspepsia are not effective for all patients. Transcutaneous electrical acustimulation (TEA) is an potentially effective therapy for functional dyspepsia without proofs of definite mechanisms. Aims We...

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Bibliographic Details
Published in:Digestive diseases and sciences 2023, Vol.68 (1), p.98-105
Main Authors: Chen, Xiaoli, Chen, Xin, Chen, Binrui, Du, Lijun, Wang, Yu, Huang, Zhihui, Dai, Ning, Chen, Jiande D. Z., Cao, Qian
Format: Article
Language:English
Subjects:
Acupuncture
Anxiety
Biochemistry
Care and treatment
Comparative analysis
Cytokines
Dyspepsia
Dyspepsia - therapy
Electroacupuncture
Endoscopy
Gastric Emptying
Gastroenterology
Health aspects
Heart beat
Heart rate
Hepatology
Hospitals
Humans
Inflammation
Informed consent
Interleukin-6
Medicine
Medicine & Public Health
Medicine, Botanic
Medicine, Herbal
Oncology
Original Article
Pathophysiology
Patients
Quality of life
Questionnaires
Stomach Diseases
Transplant Surgery
Tumor necrosis factor-TNF
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Summary:Background Due to complex pathophysiology of functional dyspepsia, medications to treat functional dyspepsia are not effective for all patients. Transcutaneous electrical acustimulation (TEA) is an potentially effective therapy for functional dyspepsia without proofs of definite mechanisms. Aims We aimed to investigate the therapeutic impacts of TEA on postprandial distress syndrome (PDS) and explore potential neuroimmune mechanisms. Methods We conducted a double-blinded, randomized, controlled trial in 30 PDS patients randomized for 4-week TEA or sham-TEA. Dyspeptic symptoms, gastric accommodation, gastric emptying and heart rate variability (HRV) were assessed. Duodenal mucosal inflammation was also evaluated. Results The dyspeptic symptoms were improved with TEA compared with sham-TEA ( P  = 0.03). The initial satiety volume and the maximum tolerable volume (MTV) were both improved after the TEA treatment, compared with the sham-TEA group ( P all 
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-022-07495-8