Cardiovascular autonomic dysfunction in multiple sclerosis—findings and relationships with clinical outcomes and fatigue severity

Objectives This study evaluates cardiovascular autonomic dysfunction (CAD) in multiple sclerosis (MS) and explores if CAD is related to clinical outcomes and fatigue severity. Methods A total of 53 MS patients (30 relapsing–remitting, RRMS; 23 progressive, PMS) and 30 healthy controls were evaluated...

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Bibliographic Details
Published in:Neurological sciences 2022-08, Vol.43 (8), p.4829-4839
Main Authors: Rzepiński, Łukasz, Zawadka-Kunikowska, Monika, Newton, Julia L., Zalewski, Paweł, Słomko, Joanna
Format: Article
Language:English
Subjects:
Autonomic nervous system
Autonomic Nervous System in Clinical Practice
Blood pressure
Clinical outcomes
Dysautonomia
Fatigue
Heart rate
Medicine
Medicine & Public Health
Multiple sclerosis
Muscle contraction
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Original Article
Parasympathetic nervous system
Patients
Psychiatry
Vagus nerve
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Summary:Objectives This study evaluates cardiovascular autonomic dysfunction (CAD) in multiple sclerosis (MS) and explores if CAD is related to clinical outcomes and fatigue severity. Methods A total of 53 MS patients (30 relapsing–remitting, RRMS; 23 progressive, PMS) and 30 healthy controls were evaluated. TaskForce® Monitor was used to assess impedance cardiography parameters, heart rate (HRV), and blood pressure (BPV) variability during head-up tilt test (HUTT). Expiration/inspiration (E/I) ratio was assessed in response to a deep breathing test. Fatigue severity was evaluated using Chalder Fatigue Scale (CFQ). Results Compared to controls, PMS patients were characterized by increased sympathetic-parasympathetic ratio at rest ( p  
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-022-06099-4