Evaluating the Role of lncRNAs in the Incidence of Cardiovascular Diseases in Androgenetic Alopecia Patients

Hair loss occurs in patients with Androgenetic Alopecia (AGA). The pattern of hair loss is different between men and women. The main cause of hair loss is increased cell apoptosis and decreased regeneration, proliferation and differentiation processes in hair follicles. Long Non-Coding RNAs (lncRNAs...

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Bibliographic Details
Published in:Cardiovascular toxicology 2022-07, Vol.22 (7), p.603-619
Main Authors: Roohaninasab, Masoumeh, yavari, Shadnaz fakhteh, Babazadeh, Motahareh, Hagh, Rozita Adldoosti, Pazoki, Mahboubeh, Amrovani, Mehran
Format: Article
Language:English
Subjects:
Alopecia
Apoptosis
Baldness
Biomedical and Life Sciences
Biomedicine
Cardiology
Cardiotoxicity
Cardiovascular diseases
Complications
Differentiation
Follicles
Hair
Hair loss
Medical research
Medicine, Experimental
Non-coding RNA
Patients
Pharmacology/Toxicology
Regeneration
Risk analysis
Risk factors
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Summary:Hair loss occurs in patients with Androgenetic Alopecia (AGA). The pattern of hair loss is different between men and women. The main cause of hair loss is increased cell apoptosis and decreased regeneration, proliferation and differentiation processes in hair follicles. Long Non-Coding RNAs (lncRNAs) are one of the most important molecules that regulate the processes of apoptosis, regeneration, proliferation and differentiation in hair follicles. Since studies have shown that lncRNAs can be effective in the development of cardiotoxicity and induction of cardiovascular disease (CVD); so effective lncRNAs in the regulation of regeneration, proliferation, differentiation and apoptosis of hair follicles can be involved in the development of CVD in AGA patients with. Therefore, this study investigated the lncRNAs involved in increasing apoptosis and reducing the processes of regeneration, proliferation and differentiation of hair follicles. The aim of the current study was to evaluate the role of lncRNAs as a risk factor in the incidence of CVD in AGA patients; it will help to design treatment strategies by targeting signaling pathways without any cardiotoxicity complications.
ISSN:1530-7905
1559-0259
DOI:10.1007/s12012-022-09742-w