Insight into the Enterovirus A71: A review

Enterovirus A71 is a major causative pathogen of hand, foot and mouth disease. It has become a global public health threat, and is especially important for infants and young children in the Asian‐Pacific countries. The enterovirus A71 is a non‐enveloped virus of the Picornaviridae family having a si...

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Bibliographic Details
Published in:Reviews in medical virology 2022-11, Vol.32 (6), p.e2361-n/a
Main Authors: Kinobe, Robert, Wiyatno, Ageng, Artika, I. Made, Safari, Dodi
Format: Article
Language:English
Subjects:
antiviral agent
Antiviral agents
biochemistry
Drug development
Enterovirus
Enterovirus A71
Enteroviruses
Epidemiology
foot and mouth disease
Genetic diversity
genetics
Genomes
Geographical distribution
hand
Hand-foot-and-mouth disease
microbiology
molecular biology
molecular epidemiology
Nonstructural proteins
Picornaviridae
Public health
Structure-function relationships
vaccine
Vaccines
virology
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Summary:Enterovirus A71 is a major causative pathogen of hand, foot and mouth disease. It has become a global public health threat, and is especially important for infants and young children in the Asian‐Pacific countries. The enterovirus A71 is a non‐enveloped virus of the Picornaviridae family having a single‐stranded positive‐sense RNA genome of about 7.4 kb which encodes the structural and nonstructural proteins. Currently there are no US FDA‐approved vaccines or antiviral therapy available against enterovirus A71 infection. Although enterovirus A71 vaccines have been licenced in China, clinically approved vaccines for widespread vaccination programs are lacking. Substantial progress has recently been achieved on understanding the structure and function of enterovirus A71 proteins together with information on the viral genetic diversity and geographic distribution. The present review is intended to provide an overview on our current understanding of the molecular biology and epidemiology of enterovirus A71 which will aid the development of vaccines, therapeutics and other control strategies so as to bolster the preparedness for future enterovirus A71 outbreaks.
ISSN:1052-9276
1099-1654
DOI:10.1002/rmv.2361