Megakaryocytes in pulmonary diseases

Megakaryocytes (MKs) are typical cellular components in the circulating blood flowing from the heart into the lungs. Physiologically, MKs function as an important regulator of platelet production and immunoregulation. However, dysfunction in MKs is considered a trigger in various diseases. It has be...

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Bibliographic Details
Published in:Life sciences (1973) 2022-07, Vol.301, p.120602-120602, Article 120602
Main Authors: Huang, Di-Yun, Wang, Guan-Ming, Ke, Zhuo-Ran, Zhou, Yong, Yang, Hui-Hui, Ma, Tian-Liang, Guan, Cha-Xiang
Format: Article
Language:English
Subjects:
Acute respiratory distress syndrome
Blood circulation
Chronic obstructive pulmonary disease
Coronavirus disease 2019
Coronaviruses
COVID-19
Fibrosis
Immunoregulation
Lung cancer
Lung diseases
Megakaryocytes
Molecular modelling
Obstructive lung disease
Outdoor air quality
Platelets
Pulmonary fibrosis
Respiratory distress syndrome
Viral diseases
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Summary:Megakaryocytes (MKs) are typical cellular components in the circulating blood flowing from the heart into the lungs. Physiologically, MKs function as an important regulator of platelet production and immunoregulation. However, dysfunction in MKs is considered a trigger in various diseases. It has been described that the lung is an important site of platelet biogenesis from extramedullary MKs, which may play an essential role in various pulmonary diseases. With detailed studies, there are different degrees of numerical changes of MKs in coronavirus disease 2019 (COVID-19), acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD), lung cancer, pulmonary fibrosis (PF), and other pulmonary diseases. Also, MKs inhibit or promote the development of pulmonary diseases through various pathways. Here, we summarize the current knowledge of MKs in pulmonary diseases, highlighting the physiological functions and integrated molecular mechanisms. We aim to shine new light on not only the subsequent study of MKs but also the diagnosis and treatment of pulmonary diseases. [Display omitted]
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2022.120602