Remnant cholesterol predicts long-term mortality of patients with metabolic dysfunction-associated fatty liver disease

Elevated serum remnant cholesterol independently predicts risks of cardiovascular diseases. However, the association between remnant cholesterol and metabolic dysfunction-associated fatty liver disease (MAFLD) remains unclear. This study aimed to explore the association of remnant cholesterol with M...

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Published in:The journal of clinical endocrinology and metabolism 2022-08, Vol.107 (8), p.e3295-e3303
Main Authors: Huang, Hangkai, Guo, Yanjun, Liu, Zhening, Zeng, Yan, Chen, Yishu, Xu, Chengfu
Format: Article
Language:English
Subjects:
Analysis
Blood lipids
Cardiovascular diseases
Cholesterol
Fatty liver
Low density lipoproteins
Medical research
Medicine, Experimental
Mortality
Patient outcomes
Prognosis
Triglycerides
Type 2 diabetes
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Summary:Elevated serum remnant cholesterol independently predicts risks of cardiovascular diseases. However, the association between remnant cholesterol and metabolic dysfunction-associated fatty liver disease (MAFLD) remains unclear. This study aimed to explore the association of remnant cholesterol with MAFLD and its long-term mortality. We extracted data from the NHANES â…˘, 1988-1994 and the linked mortality data till December 31, 2015. The association between remnant cholesterol and MAFLD was analyzed by multivariate logistic regression. Cox proportional hazards regression was performed to assess whether elevated remnant cholesterol increased all-cause and cause-specific mortalities in MAFLD patients. At baseline, 28.6% (1474/5156) of participants had MAFLD. In multivariate logistic regression, the fourth quartile of remnant cholesterol was associated with an increased risk of MAFLD compared with the first quartile (OR: 1.714, 95% CI: 1.586-1.971; P
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgac283