Eucalyptus botryoides ' resin and its new 2- O -galloyl-1,6- O -di- trans - p -coumaroyl- β -D-glycopyranoside compound display good antimicrobial activity

• Published in: Natural product research 2023-02, Vol.37 (4), p.618-627
• Main Authors: Serafim, Marcela Sayegh, Rodrigues, Débora Munhoz, Ribeiro, Victor Pena, Ccana-Ccapatinta, Gari Vidal, Groppo, Milton, Martins, Carlos Henrique Gomes, Ambrósio, Sérgio Ricardo, Bastos, A N D Jairo Kenupp
• Format: Article
• Language: English
• Subjects: Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antifungal Agents - chemistry; Antiinfectives and antibacterials; Antimicrobial activity; Bacteria; Candida krusei; Drug resistance; Ethanol; Eucalyptus; Eucalyptus botryoides; Microbial Sensitivity Tests; Minimum inhibitory concentration; Plant Extracts - chemistry; Resins; Yeast; Yeasts
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2022.2065486

Fungal resistance to different therapeutic drugs has become a growing challenge. This crucial health problem requires new effective drug alternatives. Herein, we report the study of ' resin used in folk medicine as antimicrobial. Thus, ' resin was extracted with aqueous-ethanol and fractionated using Sephadex chromatography, furnishing its major compounds. The crude extracts and the isolated compounds were evaluated for their antimicrobial activity against bacteria and yeasts. The crude extract displayed MIC of 25 μg/mL against , and for and the MIC were between 2.9 and 5.9 μg/mL. The 7- -Methyl-aromadendrin was the most effective against and (MIC = 1.6 μg/mL). 2- -Galloyl-1,6- -di- - -coumaroyl- -D-glycopyranoside, first time reported, showed MIC of 3.1 μg/mL against and . Overall, this work gave promising results, indicating that ' resin and its compounds have the potential for developing anti-yeast products.