Survival and tumor characteristics of patients presenting with single primary versus second primary melanoma lesions

Patients with single primary melanomas have an increased risk of developing subsequent melanomas. Secondary tumors diagnosed within and after 3 months are termed “synchronous” and “asynchronous,” respectively. To compare tumor distributions and survival characteristics between patients with second p...

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Published in:Journal of the American Academy of Dermatology 2023-05, Vol.88 (5), p.1033-1039
Main Authors: Sarver, Melissa M., Rames, Jess D., Beasley, Georgia M., Gao, Junheng, Jung, Sin-Ho, Chen, Suephy C.
Format: Article
Language:English
Subjects:
asynchronous melanoma
Humans
melanoma
Melanoma - diagnosis
Melanoma - pathology
Physical Examination
Retrospective Studies
second primary melanoma
single primary melanoma
Skin Neoplasms - pathology
synchronous melanoma
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cited_by cdi_FETCH-LOGICAL-c356t-7616b7dd3637d0e94bdb0c39c1ec1a01e511f1e77712e8cdcd7a2f07baeaf9963
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container_title Journal of the American Academy of Dermatology
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creator Sarver, Melissa M.
Rames, Jess D.
Beasley, Georgia M.
Gao, Junheng
Jung, Sin-Ho
Chen, Suephy C.
description Patients with single primary melanomas have an increased risk of developing subsequent melanomas. Secondary tumors diagnosed within and after 3 months are termed “synchronous” and “asynchronous,” respectively. To compare tumor distributions and survival characteristics between patients with second primary melanomas and those with single primary melanomas. Retrospective cohort study. Data were collected from an institutional database from 14,029 patients with a diagnosis of a primary melanoma seen between 1970 and 2004. The synchronous and asynchronous cohorts demonstrated significantly improved survival probabilities compared with the single primary cohort (P = .04 and .002, respectively). Single primary lesions (2.2 ± 2.3 mm) were significantly thicker than the first-identified synchronous (2.0 ± 1.7 mm) and asynchronous (1.7 ± 1.3 mm) lesions. Synchronous lesions were more likely to be anatomically concordant compared with asynchronous lesions (55.7% vs 38.2%, P 
doi_str_mv 10.1016/j.jaad.2022.04.046
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Secondary tumors diagnosed within and after 3 months are termed “synchronous” and “asynchronous,” respectively. To compare tumor distributions and survival characteristics between patients with second primary melanomas and those with single primary melanomas. Retrospective cohort study. Data were collected from an institutional database from 14,029 patients with a diagnosis of a primary melanoma seen between 1970 and 2004. The synchronous and asynchronous cohorts demonstrated significantly improved survival probabilities compared with the single primary cohort (P = .04 and .002, respectively). Single primary lesions (2.2 ± 2.3 mm) were significantly thicker than the first-identified synchronous (2.0 ± 1.7 mm) and asynchronous (1.7 ± 1.3 mm) lesions. Synchronous lesions were more likely to be anatomically concordant compared with asynchronous lesions (55.7% vs 38.2%, P &lt; .001). Single-center study design and incomplete records for second primary melanoma Breslow depth and histopathology. Patients with second primary melanomas demonstrated a significant survival advantage and thinner lesions compared with those with single primary melanomas. 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Single-center study design and incomplete records for second primary melanoma Breslow depth and histopathology. Patients with second primary melanomas demonstrated a significant survival advantage and thinner lesions compared with those with single primary melanomas. 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Single-center study design and incomplete records for second primary melanoma Breslow depth and histopathology. Patients with second primary melanomas demonstrated a significant survival advantage and thinner lesions compared with those with single primary melanomas. Our reported tumor distributions support the role of full body skin examinations, with attention to the region of initial diagnosis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>35525504</pmid><doi>10.1016/j.jaad.2022.04.046</doi><tpages>7</tpages></addata></record>
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1097-6787
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subjects asynchronous melanoma
Humans
melanoma
Melanoma - diagnosis
Melanoma - pathology
Physical Examination
Retrospective Studies
second primary melanoma
single primary melanoma
Skin Neoplasms - pathology
synchronous melanoma
title Survival and tumor characteristics of patients presenting with single primary versus second primary melanoma lesions
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