Functionalized gold nanostructures: promising gene delivery vehicles in cancer treatment

Surface-modified gold nanoparticles are recognized as promising gene delivery vehicles in the treatment of cancer owing to their excellent biocompatibility with biomolecules (like DNA or RNA) and their unique optical and structural properties. In this context, this review article focuses on the dive...

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Bibliographic Details
Published in:RSC advances 2019-08, Vol.9 (41), p.23894-2397
Main Authors: Kumar, Sanjay, Diwan, Anchita, Singh, Parinita, Gulati, Shikha, Choudhary, Devanshu, Mongia, Ayush, Shukla, Shefali, Gupta, Akanksha
Format: Article
Language:English
Subjects:
Biocompatibility
Biomolecules
Cancer
Cancer therapies
Chemistry
Deoxyribonucleic acid
DNA
Gold
Nanoparticles
Optical properties
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Summary:Surface-modified gold nanoparticles are recognized as promising gene delivery vehicles in the treatment of cancer owing to their excellent biocompatibility with biomolecules (like DNA or RNA) and their unique optical and structural properties. In this context, this review article focuses on the diverse transfection abilities of the gene to the targeted cell on the basis of different shapes and sizes of gold nanoparticles in order to promote its effective expression for cancer treatment. In addition, recent trends in gold nanoparticle mediated gene silencing, gene delivery, detection and combinatory therapies are highlighted considering their cytotoxic effects on healthy human cells. Various functions of gold nanoparticles in conjugation with nucleic acids.
ISSN:2046-2069
2046-2069
DOI:10.1039/c9ra03608c