The extracellular matrix and immunity: breaking the old barrier in cancer

Extracellular matrix (ECM) is an integral component of solid cancers; however, the impact of the ECM on antitumor immunity has remained elusive. Sun and colleagues now demonstrate that discoidin domain receptor 1-mediated collagen assembly can exclude T cells from tumors. Together, recent studies hi...

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Bibliographic Details
Published in:Trends in immunology 2022-06, Vol.43 (6), p.423-425
Main Authors: Vyas, Maulik, Demehri, Shadmehr
Format: Article
Language:English
Subjects:
Breast cancer
Cancer
Cell adhesion & migration
Chemokines
Collagen
Cytotoxicity
Discoidin Domain Receptor 1
Extracellular Matrix
Humans
Immune system
Immunocompetence
Kinases
Lymphocytes
Lymphocytes T
Neoplasms
Plastic surgery
Proteins
Skin & tissue grafts
Transplants & implants
Tumors
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Description
Summary:Extracellular matrix (ECM) is an integral component of solid cancers; however, the impact of the ECM on antitumor immunity has remained elusive. Sun and colleagues now demonstrate that discoidin domain receptor 1-mediated collagen assembly can exclude T cells from tumors. Together, recent studies highlight ECM as an active regulator of immunity in cancer.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2022.04.004