The relationship between processing speed and verbal and non-verbal new learning and memory in progressive multiple sclerosis

Objective: Processing speed (PS) deficits are the most common cognitive deficits in multiple sclerosis (MS), followed by learning and memory deficits, and are often an early cognitive problem. It has been argued that impaired PS is a primary consequence of MS, which in turn decreases learning. The c...

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Bibliographic Details
Published in:Multiple sclerosis 2022-10, Vol.28 (11), p.1783-1792
Main Authors: Chiaravalloti, Nancy D, DeLuca, John, Salter, Amber, Amato, Maria Pia, Brichetto, Giampaolo, Chataway, Jeremy, Dalgas, Ulrik, Farrell, Rachel, Feys, Peter, Filippi, Massimo, Freeman, Jennifer, Inglese, Matilde, Meza, Cecilia, Moore, Nancy B, Motl, Robert W, Rocca, Maria Assunta, Sandroff, Brian M, Cutter, Gary, Feinstein, Anthony
Format: Article
Language:English
Subjects:
Cognitive ability
Information processing
Learning
Memory
Multiple sclerosis
Rehabilitation
Spatial memory
Statistical analysis
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Summary:Objective: Processing speed (PS) deficits are the most common cognitive deficits in multiple sclerosis (MS), followed by learning and memory deficits, and are often an early cognitive problem. It has been argued that impaired PS is a primary consequence of MS, which in turn decreases learning. The current analysis examined the association between PS and learning in a large cohort of individuals with progressive MS. Methods: Baseline data from a randomized clinical trial on rehabilitation taking place at 11 centers across North America and Europe were analyzed. Participants included 275 individuals with clinically definite progressive MS (primary, secondary) consented into the trial. Results: Symbol Digit Modalities Test (SDMT) significantly correlated with California Verbal Learning Test-II (CVLT-II) (r = 0.21, p = 0.0003) and Brief Visuospatial Memory Test–Revised (BVMT-R) (r = 0.516, p 
ISSN:1352-4585
1477-0970
DOI:10.1177/13524585221088190