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Clinicopathologic and genomic characteristics of mucinous gastric adenocarcinoma
Background Mucinous gastric adenocarcinoma (MGC) is a rare but distinctive histologic subtype of gastric cancer (GC). The clinico-pathologic and genomic characteristics of MGC have not been well evaluated. Methods We collected individual data from five cohorts targeting the microsatellite instabilit...
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Published in: | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2022-07, Vol.25 (4), p.697-711 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background
Mucinous gastric adenocarcinoma (MGC) is a rare but distinctive histologic subtype of gastric cancer (GC). The clinico-pathologic and genomic characteristics of MGC have not been well evaluated.
Methods
We collected individual data from five cohorts targeting the microsatellite instability (MSI) of GC (
n
= 5089) to evaluate the clinico-pathologic characteristics of MGC. In addition, public genomic databases were used for genomic analysis. The characteristics of MGC were compared with those of non-mucinous GC (NMGC).
Results
MGC (
n
= 158, 3.1%) showed distinctive characteristics in terms of age, sex, and TNM stage compared to NMGC (
n
= 4931). MGC was frequently associated with MSI-high (OR: 2.24, 95% confidence interval [CI] 1.44–3.40,
p
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ISSN: | 1436-3291 1436-3305 |
DOI: | 10.1007/s10120-022-01295-9 |