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Clinicopathologic and genomic characteristics of mucinous gastric adenocarcinoma

Background Mucinous gastric adenocarcinoma (MGC) is a rare but distinctive histologic subtype of gastric cancer (GC). The clinico-pathologic and genomic characteristics of MGC have not been well evaluated. Methods We collected individual data from five cohorts targeting the microsatellite instabilit...

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Bibliographic Details
Published in:Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2022-07, Vol.25 (4), p.697-711
Main Authors: Lee, Jae Eun, Choi, Yoon Young, An, Ji Yeong, Kim, Ki Tae, Shin, Su-Jin, Cheong, Jae-Ho
Format: Article
Language:English
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Summary:Background Mucinous gastric adenocarcinoma (MGC) is a rare but distinctive histologic subtype of gastric cancer (GC). The clinico-pathologic and genomic characteristics of MGC have not been well evaluated. Methods We collected individual data from five cohorts targeting the microsatellite instability (MSI) of GC ( n  = 5089) to evaluate the clinico-pathologic characteristics of MGC. In addition, public genomic databases were used for genomic analysis. The characteristics of MGC were compared with those of non-mucinous GC (NMGC). Results MGC ( n  = 158, 3.1%) showed distinctive characteristics in terms of age, sex, and TNM stage compared to NMGC ( n  = 4931). MGC was frequently associated with MSI-high (OR: 2.24, 95% confidence interval [CI] 1.44–3.40, p  
ISSN:1436-3291
1436-3305
DOI:10.1007/s10120-022-01295-9