Na+ homeostasis in Acinetobacter baumannii is facilitated via the activity of the Mrp antiporter

Summary The human opportunistic pathogen Acinetobacter baumannii is a global threat to healthcare institutions worldwide, since it developed very efficient strategies to evade host defence and to adapt to the different environmental conditions of the host. This work focused on the importance of Na+...

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Bibliographic Details
Published in:Environmental microbiology 2022-09, Vol.24 (9), p.4411-4424
Main Authors: Hubloher, Josephine Joy, Sande, Lisa, Müller, Volker
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Anoxia
Defects
Environmental conditions
Fluids
Gene deletion
Homeostasis
Homology
Inactivation
Na+/H+-exchanging ATPase
Opportunist infection
Pathogens
Survival
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Summary:Summary The human opportunistic pathogen Acinetobacter baumannii is a global threat to healthcare institutions worldwide, since it developed very efficient strategies to evade host defence and to adapt to the different environmental conditions of the host. This work focused on the importance of Na+ homeostasis in A. baumannii with regards to pathobiological aspects. In silico studies revealed a homologue of a multicomponent Na+/H+ antiporter system. Inactivation of the Mrp antiporter through deletion of the first gene (mrpA′) resulted in a mutant that was sensitive to increasing pH values. Furthermore, the strain was highly sensitive to increasing Na+ and Li+ concentrations. Increasing Na+ sensitivity is thought to be responsible for growth impairment in human fluids. Furthermore, deletion of mrpA′ is associated with energetic defects, inhibition of motility and survival under anoxic and dry conditions.
ISSN:1462-2912
1462-2920
DOI:10.1111/1462-2920.16039