Association of life course adiposity with risk of incident dementia: a prospective cohort study of 322,336 participants

Cohort studies report inconsistent associations between body mass index (BMI) and all-cause incident dementia. Furthermore, evidence on fat distribution and body composition measures are scarce and few studies estimated the association between early life adiposity and dementia risk. Here, we include...

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Bibliographic Details
Published in:Molecular psychiatry 2022-08, Vol.27 (8), p.3385-3395
Main Authors: Deng, Yue-Ting, Li, Yu-Zhu, Huang, Shu-Yi, Ou, Ya-Nan, Zhang, Wei, Chen, Shi-Dong, Zhang, Ya-Ru, Yang, Liu, Dong, Qiang, Feng, Jian-Feng, Suckling, John, Smith, A. David, Cheng, Wei, Yu, Jin-Tai
Format: Article
Language:English
Subjects:
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Adipose tissue
Adiposity
Adult
Behavioral Sciences
Biological Psychology
Body composition
Body Mass Index
Body size
Child
Children
Cohort analysis
Cohort Studies
Dementia
Dementia - epidemiology
Dementia disorders
Fat-free body mass
Female
Humans
Inflammation
Leukocytes (neutrophilic)
Life Change Events
Lymphocytes
Male
Medicine
Medicine & Public Health
Metabolites
Middle Aged
Monocytes
Neurosciences
Obesity
Pharmacotherapy
Polyunsaturated fatty acids
Prospective Studies
Psychiatry
Risk Factors
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Summary:Cohort studies report inconsistent associations between body mass index (BMI) and all-cause incident dementia. Furthermore, evidence on fat distribution and body composition measures are scarce and few studies estimated the association between early life adiposity and dementia risk. Here, we included 322,336 participants from UK biobank to investigate the longitudinal association between life course adiposity and risk of all-cause incident dementia and to explore the underlying mechanisms driven by metabolites, inflammatory cells and brain structures. Among the 322,336 individuals (mean (SD) age, 62.24 (5.41) years; 53.9% women) in the study, during a median 8.74 years of follow-up, 5083 all-cause incident dementia events occurred. The risk of dementia was 22% higher with plumper childhood body size ( p  
ISSN:1359-4184
1476-5578
DOI:10.1038/s41380-022-01604-9