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Association of life course adiposity with risk of incident dementia: a prospective cohort study of 322,336 participants
Cohort studies report inconsistent associations between body mass index (BMI) and all-cause incident dementia. Furthermore, evidence on fat distribution and body composition measures are scarce and few studies estimated the association between early life adiposity and dementia risk. Here, we include...
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| Published in: | Molecular psychiatry 2022-08, Vol.27 (8), p.3385-3395 |
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| container_end_page | 3395 |
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| container_title | Molecular psychiatry |
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| creator | Deng, Yue-Ting Li, Yu-Zhu Huang, Shu-Yi Ou, Ya-Nan Zhang, Wei Chen, Shi-Dong Zhang, Ya-Ru Yang, Liu Dong, Qiang Feng, Jian-Feng Suckling, John Smith, A. David Cheng, Wei Yu, Jin-Tai |
| description | Cohort studies report inconsistent associations between body mass index (BMI) and all-cause incident dementia. Furthermore, evidence on fat distribution and body composition measures are scarce and few studies estimated the association between early life adiposity and dementia risk. Here, we included 322,336 participants from UK biobank to investigate the longitudinal association between life course adiposity and risk of all-cause incident dementia and to explore the underlying mechanisms driven by metabolites, inflammatory cells and brain structures. Among the 322,336 individuals (mean (SD) age, 62.24 (5.41) years; 53.9% women) in the study, during a median 8.74 years of follow-up, 5083 all-cause incident dementia events occurred. The risk of dementia was 22% higher with plumper childhood body size (
p
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| doi_str_mv | 10.1038/s41380-022-01604-9 |
| format | article |
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p
< 0.001). A strong U-shaped association was observed between adult BMI and dementia. More fat and less fat-free mass distribution on arms were associated with a higher risk of dementia. Interestingly, similar U-shaped associations were found between BMI and four metabolites (i.e., 3-hydroxybutrate, acetone, citrate and polyunsaturated fatty acids), four inflammatory cells (i.e., neutrophil, lymphocyte, monocyte and leukocyte) and abnormalities in brain structure that were also related to dementia. The findings that adiposity is associated with metabolites, inflammatory cells and abnormalities in brain structure that were related to dementia risk might provide clues to underlying biological mechanisms. Interventions to prevent dementia should begin early in life and include not only BMI control but fat distribution and body composition.</description><identifier>ISSN: 1359-4184</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/s41380-022-01604-9</identifier><identifier>PMID: 35538193</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/337 ; 631/378 ; Adipose tissue ; Adiposity ; Adult ; Behavioral Sciences ; Biological Psychology ; Body composition ; Body Mass Index ; Body size ; Child ; Children ; Cohort analysis ; Cohort Studies ; Dementia ; Dementia - epidemiology ; Dementia disorders ; Fat-free body mass ; Female ; Humans ; Inflammation ; Leukocytes (neutrophilic) ; Life Change Events ; Lymphocytes ; Male ; Medicine ; Medicine & Public Health ; Metabolites ; Middle Aged ; Monocytes ; Neurosciences ; Obesity ; Pharmacotherapy ; Polyunsaturated fatty acids ; Prospective Studies ; Psychiatry ; Risk Factors</subject><ispartof>Molecular psychiatry, 2022-08, Vol.27 (8), p.3385-3395</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Nature Limited.</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-c02eb9e0f097e72ff99f2d552821248a03f7b55b8cea1ea81f638a4cdaf13c6e3</citedby><cites>FETCH-LOGICAL-c375t-c02eb9e0f097e72ff99f2d552821248a03f7b55b8cea1ea81f638a4cdaf13c6e3</cites><orcidid>0000-0002-2532-383X ; 0000-0003-1118-1743 ; 0000-0002-1095-6722 ; 0000-0002-5098-1527 ; 0000-0002-3874-0130</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35538193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deng, Yue-Ting</creatorcontrib><creatorcontrib>Li, Yu-Zhu</creatorcontrib><creatorcontrib>Huang, Shu-Yi</creatorcontrib><creatorcontrib>Ou, Ya-Nan</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Chen, Shi-Dong</creatorcontrib><creatorcontrib>Zhang, Ya-Ru</creatorcontrib><creatorcontrib>Yang, Liu</creatorcontrib><creatorcontrib>Dong, Qiang</creatorcontrib><creatorcontrib>Feng, Jian-Feng</creatorcontrib><creatorcontrib>Suckling, John</creatorcontrib><creatorcontrib>Smith, A. David</creatorcontrib><creatorcontrib>Cheng, Wei</creatorcontrib><creatorcontrib>Yu, Jin-Tai</creatorcontrib><title>Association of life course adiposity with risk of incident dementia: a prospective cohort study of 322,336 participants</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>Cohort studies report inconsistent associations between body mass index (BMI) and all-cause incident dementia. Furthermore, evidence on fat distribution and body composition measures are scarce and few studies estimated the association between early life adiposity and dementia risk. Here, we included 322,336 participants from UK biobank to investigate the longitudinal association between life course adiposity and risk of all-cause incident dementia and to explore the underlying mechanisms driven by metabolites, inflammatory cells and brain structures. Among the 322,336 individuals (mean (SD) age, 62.24 (5.41) years; 53.9% women) in the study, during a median 8.74 years of follow-up, 5083 all-cause incident dementia events occurred. The risk of dementia was 22% higher with plumper childhood body size (
p
< 0.001). A strong U-shaped association was observed between adult BMI and dementia. More fat and less fat-free mass distribution on arms were associated with a higher risk of dementia. Interestingly, similar U-shaped associations were found between BMI and four metabolites (i.e., 3-hydroxybutrate, acetone, citrate and polyunsaturated fatty acids), four inflammatory cells (i.e., neutrophil, lymphocyte, monocyte and leukocyte) and abnormalities in brain structure that were also related to dementia. The findings that adiposity is associated with metabolites, inflammatory cells and abnormalities in brain structure that were related to dementia risk might provide clues to underlying biological mechanisms. Interventions to prevent dementia should begin early in life and include not only BMI control but fat distribution and body composition.</description><subject>631/337</subject><subject>631/378</subject><subject>Adipose tissue</subject><subject>Adiposity</subject><subject>Adult</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Body composition</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Child</subject><subject>Children</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Dementia</subject><subject>Dementia - epidemiology</subject><subject>Dementia disorders</subject><subject>Fat-free body mass</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Leukocytes (neutrophilic)</subject><subject>Life Change Events</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Monocytes</subject><subject>Neurosciences</subject><subject>Obesity</subject><subject>Pharmacotherapy</subject><subject>Polyunsaturated fatty acids</subject><subject>Prospective Studies</subject><subject>Psychiatry</subject><subject>Risk Factors</subject><issn>1359-4184</issn><issn>1476-5578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kU1P3DAQhq0KxPcf6KGyxKUHQv2ZONwQgrYSEhd6trzOuGu6m6Qep2j_PQ67bSUOnMbSPO8743kJ-cjZJWfSfEHFpWEVE6JivGaqaj-QI66autK6MXvlLXVbKW7UITlGfGJsbuoDcii1loa38og8XyMOProch54Oga5iAOqHKSFQ18VxwJg39DnmJU0Rf81I7H3soM-0g3Up0V1RR8c04Ag-xz-zfDmkTDFP3WYWSCEupKzp6FKOPo6uz3hK9oNbIZzt6gn5cXf7ePOtun_4-v3m-r7ystG58kzAogUWWNtAI0Jo2yA6rYURXCjjmAzNQuuF8eA4OMNDLY1TvnOBS1-DPCGft75lwd8TYLbriB5WK9fDMKEVdS3KLbSSBT1_gz6VO_RlOysaxbkqE3mhxJby5ceYINgxxbVLG8uZnWOx21hsicW-xmLbIvq0s54Wa-j-Sf7mUAC5BbC0-p-Q_s9-x_YF_GKYiw</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Deng, Yue-Ting</creator><creator>Li, Yu-Zhu</creator><creator>Huang, Shu-Yi</creator><creator>Ou, Ya-Nan</creator><creator>Zhang, Wei</creator><creator>Chen, Shi-Dong</creator><creator>Zhang, Ya-Ru</creator><creator>Yang, Liu</creator><creator>Dong, Qiang</creator><creator>Feng, Jian-Feng</creator><creator>Suckling, John</creator><creator>Smith, A. 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David</au><au>Cheng, Wei</au><au>Yu, Jin-Tai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of life course adiposity with risk of incident dementia: a prospective cohort study of 322,336 participants</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>27</volume><issue>8</issue><spage>3385</spage><epage>3395</epage><pages>3385-3395</pages><issn>1359-4184</issn><eissn>1476-5578</eissn><abstract>Cohort studies report inconsistent associations between body mass index (BMI) and all-cause incident dementia. Furthermore, evidence on fat distribution and body composition measures are scarce and few studies estimated the association between early life adiposity and dementia risk. Here, we included 322,336 participants from UK biobank to investigate the longitudinal association between life course adiposity and risk of all-cause incident dementia and to explore the underlying mechanisms driven by metabolites, inflammatory cells and brain structures. Among the 322,336 individuals (mean (SD) age, 62.24 (5.41) years; 53.9% women) in the study, during a median 8.74 years of follow-up, 5083 all-cause incident dementia events occurred. The risk of dementia was 22% higher with plumper childhood body size (
p
< 0.001). A strong U-shaped association was observed between adult BMI and dementia. More fat and less fat-free mass distribution on arms were associated with a higher risk of dementia. Interestingly, similar U-shaped associations were found between BMI and four metabolites (i.e., 3-hydroxybutrate, acetone, citrate and polyunsaturated fatty acids), four inflammatory cells (i.e., neutrophil, lymphocyte, monocyte and leukocyte) and abnormalities in brain structure that were also related to dementia. The findings that adiposity is associated with metabolites, inflammatory cells and abnormalities in brain structure that were related to dementia risk might provide clues to underlying biological mechanisms. Interventions to prevent dementia should begin early in life and include not only BMI control but fat distribution and body composition.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>35538193</pmid><doi>10.1038/s41380-022-01604-9</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2532-383X</orcidid><orcidid>https://orcid.org/0000-0003-1118-1743</orcidid><orcidid>https://orcid.org/0000-0002-1095-6722</orcidid><orcidid>https://orcid.org/0000-0002-5098-1527</orcidid><orcidid>https://orcid.org/0000-0002-3874-0130</orcidid></addata></record> |
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| subjects | 631/337 631/378 Adipose tissue Adiposity Adult Behavioral Sciences Biological Psychology Body composition Body Mass Index Body size Child Children Cohort analysis Cohort Studies Dementia Dementia - epidemiology Dementia disorders Fat-free body mass Female Humans Inflammation Leukocytes (neutrophilic) Life Change Events Lymphocytes Male Medicine Medicine & Public Health Metabolites Middle Aged Monocytes Neurosciences Obesity Pharmacotherapy Polyunsaturated fatty acids Prospective Studies Psychiatry Risk Factors |
| title | Association of life course adiposity with risk of incident dementia: a prospective cohort study of 322,336 participants |
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