Enzyme replacement therapy leading to improvement in myeloma indices in a patient with concomitant Gaucher disease

Patients with Gaucher disease (GD) have been shown previously to carry an increased risk for cancer, most commonly multiple myeloma (MM). It is currently unknown whether treatment for GD has an effect on the prevention or amelioration of MM. We present the case of a 41‐year‐old patient simultaneousl...

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Bibliographic Details
Published in:Internal medicine journal 2022-05, Vol.52 (5), p.872-875
Main Authors: Harel, Reut, Gavish, Israel, Aviv, Ariel, Greenman Maravi, Nofar, Trougouboff, Philippe, Zimran, Ari, Revel‐Vilk, Shoshana
Format: Article
Language:English
Subjects:
enzyme replacement therapy
Enzymes
Gaucher disease
Gaucher's disease
monoclonal gammopathy of unknown significance (MGUS)
Multiple myeloma
Patients
polyclonal gammopathy
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Summary:Patients with Gaucher disease (GD) have been shown previously to carry an increased risk for cancer, most commonly multiple myeloma (MM). It is currently unknown whether treatment for GD has an effect on the prevention or amelioration of MM. We present the case of a 41‐year‐old patient simultaneously diagnosed with GD and smouldering MM. Enzyme replacement therapy with Velaglucerase‐alfa significantly improved myeloma indices.
ISSN:1444-0903
1445-5994
DOI:10.1111/imj.15781