A comparison of frozen-thawed embryo transfer protocols in 2920 single-blastocyst transfers

Objective To assess the effect of frozen-thawed embryo transfer (FET) protocol on live-birth rate (LBR) and clinical pregnancy rate (CPR), in single-vitrified-blastocyst transfer Materials and methods Retrospective cohort study with FET of a single-blastocyst embryos ( n  = 2920 cycles) thawed 2013–...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2022-09, Vol.306 (3), p.887-892
Main Authors: Kadour-Peero, Einav, Feferkorn, Ido, Bellemare, Veronique, Arab, Suha, Buckett, William
Format: Article
Language:English
Subjects:
Birth rate
Cryopreservation
Embryos
Endocrinology
Endometrium
Gestational age
Gynecologic Endocrinology and Reproductive Medicine
Gynecology
Hormone replacement therapy
Human Genetics
Infertility
Medicine
Medicine & Public Health
Obstetrics
Obstetrics/Perinatology/Midwifery
Ovaries
Pregnancy
Statistical analysis
Ultrasonic imaging
Vagina
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Summary:Objective To assess the effect of frozen-thawed embryo transfer (FET) protocol on live-birth rate (LBR) and clinical pregnancy rate (CPR), in single-vitrified-blastocyst transfer Materials and methods Retrospective cohort study with FET of a single-blastocyst embryos ( n  = 2920 cycles) thawed 2013–2018. FET protocols were natural cycles (NC-FET) ( n  = 147), artificial hormone replacement treatment cycles (HRT-FET) ( n  = 2645), and modified NC (mNC) with hCG triggering ( n  = 128). Primary outcome was LBR. Adjustment for age, embryo grade, year of freezing\thawing, infertility cause, and endometrial thickness was performed. Results There were no significant differences between the groups with regard to female age, embryo grade, and endometrial thickness. LBR was higher in the mNC compared to HRT-FET cycles (38.3% vs. 20.9% P  
ISSN:1432-0711
0932-0067
1432-0711
DOI:10.1007/s00404-022-06588-z