Leptin and its relationship with magnesium biomarkers in women with obesity

Some studies have demonstrated the participation of leptin in magnesium metabolism. On the other hand, there is evidence of the role of magnesium in the leptin intracellular signaling pathway. Therefore, the aim of this study was to investigate the existence of a relationship between serum leptin co...

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Published in:Biometals 2022-08, Vol.35 (4), p.689-697
Main Authors: de Sousa Melo, Stéfany Rodrigues, dos Santos, Loanne Rocha, Morais, Jennifer Beatriz Silva, Cruz, Kyria Jayanne Clímaco, de Oliveira, Ana Raquel Soares, da Silva, Nilmara Cunha, de Sousa, Gustavo Santos, Payolla, Tanyara Baliani, Murata, Gilson, Bordin, Silvana, Henriques, Gilberto Simeone, do Nascimento Marreiro, Dilina
Format: Article
Language:English
Subjects:
Biochemistry
Biomarkers
Biomedical and Life Sciences
Body mass index
Body size
Body weight
Cell Biology
Dietary intake
Erythrocytes
Intracellular signalling
Leptin
Life Sciences
Magnesium
Medicine/Public Health
Microbiology
Nutritional status
Obesity
Pharmacology/Toxicology
Plant Physiology
Signal transduction
Statistical analysis
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Summary:Some studies have demonstrated the participation of leptin in magnesium metabolism. On the other hand, there is evidence of the role of magnesium in the leptin intracellular signaling pathway. Therefore, the aim of this study was to investigate the existence of a relationship between serum leptin concentrations and magnesium biomarkers in women with obesity. Case–control study involving 108 women aged between 20 and 50 years, divided into two groups: obese (n = 52) and control (n = 56). Body weight, height and waist circumference, body mass index, dietary magnesium intake, magnesium biomarkers and serum leptin concentrations were measured. Serum leptin concentrations showed a statistically significant difference between groups (p  0.05). Women with obesity had lower plasma and erythrocyte magnesium concentrations than control group did (p 
ISSN:0966-0844
1572-8773
DOI:10.1007/s10534-022-00393-6