Large-scale human tissue analysis identifies Uroplakin 1b as a putative diagnostic marker in surgical pathology

Uroplakin 1B (Upk1b) stabilizes epithelial cells lining the bladder lumen to prevent rupturing during bladder distension. Little is known about Upk1b expression in other normal and malignant tissues. To comprehensively evaluate the potential diagnostic and prognostic utility of Upk1b expression anal...

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Published in:Human pathology 2022-08, Vol.126, p.108-120
Main Authors: Reiswich, Viktor, Akdeniz, Gonca, Lennartz, Maximilian, Menz, Anne, Chirico, Viktoria, Hube-Magg, Claudia, Fraune, Christoph, Bernreuther, Christian, Simon, Ronald, Clauditz, Till S., Sauter, Guido, Uhlig, Ria, Hinsch, Andrea, Kind, Simon, Jacobsen, Frank, Möller, Katharina, Steurer, Stefan, Minner, Sarah, Burandt, Eike, Marx, Andreas H., Lebok, Patrick, Krech, Till, Dum, David
Format: Article
Language:English
Subjects:
Bladder cancer
Diagnostic marker
Endometrial cancer
Endometrium
Fallopian tubes
Gallbladder
Immunohistochemistry
Lung cancer
Mesothelioma
Metastasis
Ovarian cancer
Pathology
Prostate
Protein expression
Proteins
Signal transduction
Tissue microarray
Tumors
Uroplakin1b
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Summary:Uroplakin 1B (Upk1b) stabilizes epithelial cells lining the bladder lumen to prevent rupturing during bladder distension. Little is known about Upk1b expression in other normal and malignant tissues. To comprehensively evaluate the potential diagnostic and prognostic utility of Upk1b expression analysis, a tissue microarray containing 14,061 samples from 127 different tumor types and subtypes and 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. Upk1b immunostaining was found in 61 (48%) different tumor types including 50 (39%) with at least one moderately positive and 39 tumor types (31%) with at least one strongly positive tumor. Highest positivity rates were found in urothelial neoplasms (58–95%), Brenner tumors of the ovary (92%), epithelioid mesothelioma (87%), serous carcinoma of the ovary (58%) and the endometrium (53%) as well as in squamous cell carcinoma of the head and neck (18–37%), lung (39%), and esophagus (26%). In urothelial carcinoma, low Upk1b expression was linked to high grade and invasive tumor growth (P 
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2022.05.002