PEG-mesoporous material modified by superparamagnetic nanoparticles as a delivery system of cefotaxime

The fight against infectious bacterial diseases has been taking major steps forward by designing new nanodrugs and nanoscale biological carriers with unique physicochemical properties. Here, polyethylene glycol (PEG)-silica mesoporous material/superparamagnetic CuFe 2 O 4 nanoparticle nanocomposite...

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Bibliographic Details
Published in:Archives of microbiology 2022-06, Vol.204 (6), p.322-322, Article 322
Main Authors: Salehi, Amin, Behpour, Mohsen, Afzali, Daryoush
Format: Article
Language:English
Subjects:
Antibacterial activity
Bacteria
Bacterial diseases
Biochemistry
Biomedical and Life Sciences
Biotechnology
Cefotaxime
Cell Biology
Chemical synthesis
Drug carriers
Drug delivery
E coli
Ecology
Gram-negative bacteria
Gram-positive bacteria
Life Sciences
Microbial Ecology
Microbiology
Nanocomposites
Nanoparticles
Original Paper
Physicochemical properties
Polyethylene glycol
Silica
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Summary:The fight against infectious bacterial diseases has been taking major steps forward by designing new nanodrugs and nanoscale biological carriers with unique physicochemical properties. Here, polyethylene glycol (PEG)-silica mesoporous material/superparamagnetic CuFe 2 O 4 nanoparticle nanocomposite was synthesized using a facile chemical approach, and proposed as a carrier for the delivery of cefotaxime (CTX) drug. The resulting nanocomposite material and nanocomposite CTX drug carrier were characterized by different techniques. Antibacterial activity of the nanocomposite drug carrier was investigated against E.coli and S. aureus bacteria, and compared with that of commercial CTX drug. It was found that the minimum inhibitory concentrations of the nanocomposite drug carrier (1.25 and 5 μg/mL) were significantly less than those of the commercial drug (10 and 80 μg/mL) against the bacteria. Furthermore, enhanced performance of the nanocomposite CTX carrier for both the Gram-negative and Gram-positive bacteria was evidenced.
ISSN:0302-8933
1432-072X
DOI:10.1007/s00203-022-02937-3