T cells: a ‘hidden corner’ to be explored for treating heart failure

Graphical Abstract Graphical Abstract Schematic showing that physiological T-cell development correlated with the loss of cardiac regenerative potential in post-natal mice, and adoptive transfer of adult T cells into neonates prolonged inflammation and inhibited myocardial regeneration in an IFN-γ-d...

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Bibliographic Details
Published in:European heart journal 2022-07, Vol.43 (28), p.2710-2712
Main Authors: Zhu, Yike, Ackers-Johnson, Matthew, Foo, Roger
Format: Article
Language:English
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Summary:Graphical Abstract Graphical Abstract Schematic showing that physiological T-cell development correlated with the loss of cardiac regenerative potential in post-natal mice, and adoptive transfer of adult T cells into neonates prolonged inflammation and inhibited myocardial regeneration in an IFN-γ-dependent manner (Dolejsi et al.6). Related to other immune cells in heart regeneration, the specific contribution of T-cell subpopulations are depicted. Dotted arrows represent possible future studies, including the converse adoptive cell transfer.
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehac241