Three New Pregnanes Isolated from the Cynanchum auriculatum

Three new compounds named cynansteroid A (1), cynansteroid B (2) and cynansteroid C (3), together with nine known C21‐steroidal pregnane sapogenins (4–12) were isolated from the hydrolytic extract of the roots of Cynanchum auriculatum. The structures of cynansteroid A–C (1–3) were ascertained via th...

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Bibliographic Details
Published in:Chemistry & biodiversity 2022-06, Vol.19 (6), p.e202200243-n/a
Main Authors: Fan, Yi‐Min, Jin, Jun, Jian, Jun‐You, Gu, Wei, Yuan, Chun‐Mao, Hu, Zhan‐Xing, Hao, Xiao‐Jiang, Huang, Lie‐Jun
Format: Article
Language:English
Subjects:
Cynanchum auriculatum
NMR
Nuclear magnetic resonance
Phomopsis
pregnanes
Sapogenins
Verticillium dahliae
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Summary:Three new compounds named cynansteroid A (1), cynansteroid B (2) and cynansteroid C (3), together with nine known C21‐steroidal pregnane sapogenins (4–12) were isolated from the hydrolytic extract of the roots of Cynanchum auriculatum. The structures of cynansteroid A–C (1–3) were ascertained via the detailed analysis of the HR‐ESI‐MS, 1D and 2D NMR, and the calculated and experimental ECD data of cynansteroid B (2). Compound 11 displayed moderate inhibitory activity toward Verticillium dahliae Kleb (IC50=37.15 μM), furthermore, compounds 11 and 12 showed significant inhibitory activity against Phomopsis sp. (IC50=16.49 μM and 17.62 μM, respectively).
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202200243