Three New Pregnanes Isolated from the Cynanchum auriculatum

Three new compounds named cynansteroid A (1), cynansteroid B (2) and cynansteroid C (3), together with nine known C21‐steroidal pregnane sapogenins (4–12) were isolated from the hydrolytic extract of the roots of Cynanchum auriculatum. The structures of cynansteroid A–C (1–3) were ascertained via th...

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Published in:Chemistry & biodiversity 2022-06, Vol.19 (6), p.e202200243-n/a
Main Authors: Fan, Yi‐Min, Jin, Jun, Jian, Jun‐You, Gu, Wei, Yuan, Chun‐Mao, Hu, Zhan‐Xing, Hao, Xiao‐Jiang, Huang, Lie‐Jun
Format: Article
Language:English
Subjects:
Cynanchum auriculatum
NMR
Nuclear magnetic resonance
Phomopsis
pregnanes
Sapogenins
Verticillium dahliae
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container_start_page e202200243
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creator Fan, Yi‐Min
Jin, Jun
Jian, Jun‐You
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Yuan, Chun‐Mao
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Hao, Xiao‐Jiang
Huang, Lie‐Jun
description Three new compounds named cynansteroid A (1), cynansteroid B (2) and cynansteroid C (3), together with nine known C21‐steroidal pregnane sapogenins (4–12) were isolated from the hydrolytic extract of the roots of Cynanchum auriculatum. The structures of cynansteroid A–C (1–3) were ascertained via the detailed analysis of the HR‐ESI‐MS, 1D and 2D NMR, and the calculated and experimental ECD data of cynansteroid B (2). Compound 11 displayed moderate inhibitory activity toward Verticillium dahliae Kleb (IC50=37.15 μM), furthermore, compounds 11 and 12 showed significant inhibitory activity against Phomopsis sp. (IC50=16.49 μM and 17.62 μM, respectively).
doi_str_mv 10.1002/cbdv.202200243
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source Wiley-Blackwell Read & Publish Collection
subjects Cynanchum auriculatum
NMR
Nuclear magnetic resonance
Phomopsis
pregnanes
Sapogenins
Verticillium dahliae
title Three New Pregnanes Isolated from the Cynanchum auriculatum
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