Recent advancements in coralyne (COR)-based biosensors: Basic principles, various strategies and future perspectives

As a kind of protoberberine alkaloid heterocyclic analogues, coralyne (COR) has been reported to exhibit superior antileukemic ability and used as anticancer drug agent. While, the severe hazards and side effects caused by unreasonable use have made its accurate detection more and more important. Al...

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Published in:Biosensors & bioelectronics 2022-08, Vol.210, p.114343-114343, Article 114343
Main Authors: Han, Jiawen, Wang, Juan, Wang, Jun, Fan, Daoqing, Dong, Shaojun
Format: Article
Language:English
Subjects:
AuNPs
Colorimetric
Coralyne (COR) detection
Enzyme-assisted amplification
Fluorescent
Nanozyme
Non-COR targets detection
Poly-A strand
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Summary:As a kind of protoberberine alkaloid heterocyclic analogues, coralyne (COR) has been reported to exhibit superior antileukemic ability and used as anticancer drug agent. While, the severe hazards and side effects caused by unreasonable use have made its accurate detection more and more important. Although scientists have explored various methods to sense COR and other related targets, a systematical review which could not only elaborate recent developments and analyze current challenges of COR-based biosensors, but also present future perspective has not been reported and is urgently needed. In this review, we attempt to summarize latest advancements in COR-based biosensors in recent decade. Firstly, the operating principles, advantages and disadvantages of various strategies for COR detection (colorimetric, fluorescent, electrochemical and other ones) are comprehensively demonstrated and reviewed. Secondly, COR-assisted biosensors for detection of different non-COR targets (heparin, toxins, nucleic acids and other small molecules) are further discussed. Finally, we analyze current challenges and also suggest potential perspectives for this area. [Display omitted] •Advancements in COR-based biosensors in recent decade are reviewed for the first time.•Operating principles, latest achievements of various strategies for COR detection are demonstrated.•COR-assisted biosensors for different non-COR targets detection are further discussed.•Challenges and perspectives are analyzed and suggested.
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2022.114343