Phytochemical-conjugated bio-safe gold nanoparticles in breast cancer: a comprehensive update

Breast cancer is the most common malignancy in women and is rated among one of the three common malignancies worldwide in combination with colon and lung cancer. The escalating mortality rate of breast cancer patients has captivated the attention of the present-day researchers to come up with new ma...

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Bibliographic Details
Published in:Breast cancer (Tokyo, Japan) Japan), 2022-09, Vol.29 (5), p.761-777
Main Authors: Roy, Partha, Sur, Srija, Das, Suvadra, Wui, Wong Tin
Format: Article
Language:English
Subjects:
Adjuvant treatment
Breast cancer
Cancer
Cancer Research
Care and treatment
Diagnosis
Health aspects
Medicine
Medicine & Public Health
Nanoparticles
Oncology
Oncology, Experimental
Radiotherapy
Review Article
Surgery
Surgical Oncology
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Summary:Breast cancer is the most common malignancy in women and is rated among one of the three common malignancies worldwide in combination with colon and lung cancer. The escalating mortality rate of breast cancer patients has captivated the attention of the present-day researchers to come up with new management options. According to WHO, early detection, timely diagnosis and comprehensive breast cancer management are the three cornerstones for controlling breast cancer incidences per year. Multidisciplinary theragnostic approaches for simultaneous diagnosis and treatment of breast cancer have further enriched the therapeutic arsenal. Imaging and biopsy play a significant role in the diagnosis of breast cancer. The treatment plan mostly initiates with general surgery or radiation therapy followed up with adjuvant and/or neoadjuvant therapy. Conventional chemotherapeutics in breast cancer suffer from toxicity and lack of site specificity. Bio-safe gold nanoparticles hold sufficient promise for bridging this gap. Diverse phytochemicals-based synthesis routes to arrive at nano-dimensional gold with spotlight on reaction mechanisms, reaction variables, specific advantages, toxicity and their influence in breast cancer conditions are the focus of this work. This review marks the first attempt to explore the potential of phytochemical-derived nano-gold in breast cancer treatment.
ISSN:1340-6868
1880-4233
DOI:10.1007/s12282-022-01368-8