A systematic study on phenotypical characteristics of invasive breast carcinoma and surrounding ductal carcinoma in situ in multifocal breast cancers

Multifocal breast cancers are heterogeneous in terms of histologic characteristics and molecular types. In this study, we annotated multiple foci of invasive lesions and DCIS (ductal carcinoma in situ) lesions of 17 cases of multifocal breast cancer and investigated their immunohistochemical phenoty...

Full description

Saved in:
Bibliographic Details
Published in:Human pathology 2022-09, Vol.127, p.12-20
Main Authors: Jeon, Taesung, Kim, Hayeon, Kim, Aeree, Kim, Chungyeul
Format: Article
Language:English
Subjects:
Biomarkers
Breast cancer
Genotype & phenotype
immunohistochemistry
molecular type
Monoclonal antibodies
multifocal
Pathophysiology
Patients
proliferative index
Software
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Multifocal breast cancers are heterogeneous in terms of histologic characteristics and molecular types. In this study, we annotated multiple foci of invasive lesions and DCIS (ductal carcinoma in situ) lesions of 17 cases of multifocal breast cancer and investigated their immunohistochemical phenotypes (ER (estrogen receptor), PR (progesterone receptor), HER2 (human epidermal growth factor 2), Ki-67 proliferative index). Tumor histologic grade, proliferative index, and phenotypes were varied within each patient. We observed that there were some cases in which the treatment consideration could be changed due to different phenotypes of lesions. The proliferative index tended to be higher in areas where the histologic grade was higher. The TN (triple-negative) type had the highest Ki-67 index, followed by luminal B/HER2-, HER2, luminal B/HER2+, and luminal A types sequentially. As the luminal B lesions comprised a considerable portion of multifocal cancer, we subcategorized them according to several criteria. The proliferation index of the luminal B group was significantly (p < 0.001) higher in the low HR (hormone receptor) group than in the HR group. When compared by the phenotypes of the surrounding lesions, the proliferative index of luminal B lesions were intimately related to the coexisting phenotypes. In conclusion, the immunohistochemical phenotypes of multifocal breast cancer are heterogeneous, and luminal B type is the commonest of the heterogeneous phenotypes.
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2022.05.005