Clinical outcome of photodynamic therapy for the treatment of cervical intraepithelial neoplasia grade 2

•ALA-PDT was used to treat 79 CIN-2 patients.•Full recovery and improvement rates were 43/65 and 16/65, respectively.•Thus, ALA-PDT can be applied as monotherapy clinically. Five-aminolaevulinic acid photodynamic therapy (ALA-PDT) was used to treat 79 cervical intraepithelial neoplasia 2 (CIN 2) pat...

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Bibliographic Details
Published in:Photodiagnosis and photodynamic therapy 2022-09, Vol.39, p.102906-102906, Article 102906
Main Authors: Cai, Huihui, Che, Yanci, Sun, Xin, Yu, Xiao, Yu, Fengsheng, Hou, Feng, Wang, Yankui, Ma, Tingting
Format: Article
Language:English
Subjects:
CD4
Cervical intraepithelial neoplasia 2
Human
Immunology
Photodynamic therapy
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Summary:•ALA-PDT was used to treat 79 CIN-2 patients.•Full recovery and improvement rates were 43/65 and 16/65, respectively.•Thus, ALA-PDT can be applied as monotherapy clinically. Five-aminolaevulinic acid photodynamic therapy (ALA-PDT) was used to treat 79 cervical intraepithelial neoplasia 2 (CIN 2) patients who desired preservation of fertility ,between Oct 2018 and Dec 2020. Three months after treatment, among the 65 patients who returned for follow-up, full recovery and improvement rates were 43/65 and 16/65, respectively, resulting in a total response rate of 90.77%. This suggests that ALA-PDT is worthy of clinical application, even as monotherapy. The result of immune testing also indicated significant promotion of CD4+T expression during the recovery process, highlighting the importance of immune responses in different prognoses.
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2022.102906