Serum IL‐17A concentration and a IL17RA single nucleotide polymorphism contribute to the risk of autoimmune type 1 diabetes

Aims Interleukin (IL)‐17 is associated with autoimmunity. This study aimed to affirm the role of IL‐17A, IL‐17F and single nucleotide polymorphisms (SNPs) in genes related to them and their receptors in autoimmune type 1 diabetes (T1D) for Chinese population. Methods In this study, 130 patients with...

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Published in:Diabetes/metabolism research and reviews 2022-09, Vol.38 (6), p.e3547-n/a
Main Authors: Li, Junxian, Xu, Lei, Zhao, Weijing, Pan, Jiemin, Lu, Junxi, Lu, Huijuan, Yan, Jinhua, Weng, Jianping, Liu, Fang
Format: Article
Language:English
Subjects:
Autoimmunity
Body mass index
C-reactive protein
Cytokines
Diabetes
Diabetes mellitus (insulin dependent)
Enzyme-linked immunosorbent assay
Gene polymorphism
Genotype & phenotype
Glutamate decarboxylase
Glutamic acid
Interleukin 17
interleukin 17 receptor A
Interleukin 6
interleukin‐17A
interleukin‐17F
Patients
Population studies
Risk factors
Serum levels
Single-nucleotide polymorphism
type 1 diabetes
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Summary:Aims Interleukin (IL)‐17 is associated with autoimmunity. This study aimed to affirm the role of IL‐17A, IL‐17F and single nucleotide polymorphisms (SNPs) in genes related to them and their receptors in autoimmune type 1 diabetes (T1D) for Chinese population. Methods In this study, 130 patients with autoimmune T1D and 140 non‐T1D controls were included for analysis. Clinical and biochemical data were collected, and serum levels of IL‐17A, IL‐17F, IL‐6, and high‐sensitivity C reactive protein were measured using ELISA. The SNPs rs2275913, rs8193036, rs3819025, rs763780, rs879577, rs4819554, and rs708567 were genotyped using the SNaPshot assay. Results IL‐17A levels were higher in patients with autoimmune T1D than in controls (median [IQR] 28.83[37.38] vs. 16.68[8.10], p 
ISSN:1520-7552
1520-7560
DOI:10.1002/dmrr.3547