Renal denervation in patients who do not respond to cardiac resynchronization therapy

Cardiac resynchronization therapy (CRT) reduces the morbidity and mortality in advanced heart failure (HF) in about two-thirds of the patients. Approximately one-third of the patients do not respond to CRT. The overactivity of sympathetic nervous system is associated with advanced HF and deteriorate...

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Bibliographic Details
Published in:Scandinavian cardiovascular journal : SCJ 2022-12, Vol.56 (1), p.103-106
Main Authors: Pietilä-Effati, Päivi, Höglund, Mathias, Käräjämäki, Aki, Höglund, Filip, Nabb, Anne-Maria, Matila, Eija, Koistinen, M. Juhani
Format: Article
Language:English
Subjects:
6-minute walking test
Cardiac resynchronization therapy
Cardiac Resynchronization Therapy - adverse effects
CRT nonresponder
Denervation
heart failure
Heart Failure - diagnosis
Heart Failure - therapy
Humans
renal sympathetic denervation
Treatment Outcome
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Summary:Cardiac resynchronization therapy (CRT) reduces the morbidity and mortality in advanced heart failure (HF) in about two-thirds of the patients. Approximately one-third of the patients do not respond to CRT. The overactivity of sympathetic nervous system is associated with advanced HF and deteriorates the hemodynamic state. We tested the hypothesis that controlling sympathetic overactivity by renal denervation (RDN) could be beneficial in nonresponders for CRT. In our HeartF-RDN study (ClinalTrials.gov. NCT02638324), RDN could not reverse the progression of HF in subjects with New York Heart Association Classification (NYHA) III-IV stage symptoms.
ISSN:1401-7431
1651-2006
DOI:10.1080/14017431.2022.2060526