Clinical and histopathological features related to time to complete remission in adult-onset minimal change nephrotic syndrome patients with corticosteroid treatment

• Published in: Clinical and experimental nephrology 2022-10, Vol.26 (10), p.955-962
• Main Authors: Morioka, Fumiyuki, Nakatani, Shinya, Nishide, Kozo, Machiba, Yuri, Uedono, Hideki, Tsuda, Akihiro, Ishimura, Eiji, Mori, Katsuhito, Emoto, Masanori
• Format: Article
• Language: English
• Subjects: Biopsy; Body weight; Creatinine; Edema; Kidney diseases; Medicine; Medicine & Public Health; Nephrology; Nephrotic syndrome; Original Article; Patients; Proteins; Remission; Steroids; Urology
• ISSN: 1342-1751; 1437-7799
• DOI: 10.1007/s10157-022-02235-8

Background Minimal change nephrotic syndrome (MCNS) is a common type of nephrotic syndrome in adults, though evidence regarding its clinical and histopathological features related to time to complete remission (CR) is limited. Methods This was a retrospective study of biopsy-proven, first-onset, adult MCNS patients who achieved CR after undergoing corticosteroid treatment. Body weight (BW) change rate was calculated as follows: (BW at admission − BW at discharge)/BW at discharge × 100. Histopathological examinations were performed, with particular attention given to tubulointerstitial lesions. Results Fifty-seven patients (median 41 years old, range 22–63 years; 37 males) were diagnosed with MCNS from 2007 to 2020. Time to CR was a median 11 (8–21) days. In addition to serum creatinine and urinary protein, BW change rate also showed a positive correlation with time to CR ( r s  = 0.438, p