Waitlist and posttransplant outcomes of critically ill infants awaiting heart transplantation managed without ventricular assist device support

• Published in: Pediatric transplantation 2022-09, Vol.26 (6), p.e14308-n/a
• Main Authors: Frandsen, Erik L., Banker, Katherine A., Mazor, Robert L., McMullan, D. Michael, Law, Yuk M., Kemna, Mariska S., Albers, Erin L., Hong, Borah J., Friedland‐Little, Joshua M.
• Format: Article
• Language: English
• Subjects: Coronary artery disease; Extracorporeal membrane oxygenation; Heart diseases; heart transplant; Heart transplantation; Heart transplants; infant; Infants; Mechanical ventilation; Morbidity; Mortality; outcomes; Oxygenation; Renal function; Survival; Ventilation; Ventilators; Ventricle; ventricular assist device; waitlist
• ISSN: 1397-3142; 1399-3046
• DOI: 10.1111/petr.14308

Background Infants listed for heart transplant are at high risk for waitlist mortality. While waitlist mortality for children has decreased in the current era of increased ventricular assist device use, outcomes for small infants supported by ventricular assist device remain suboptimal. We evaluated morbidity and survival in critically ill infants listed for heart transplant and managed without ventricular assist device support. Methods Critically ill infants (requiring ≥1 inotrope and mechanical ventilation or ≥2 inotropes without mechanical ventilation) listed between 2008 and 2019 were included. During the study period, infants were managed primarily medically. Mechanical circulatory support, specifically extracorporeal membrane oxygenation, was utilized as “rescue therapy” for decompensating patients. Results Thirty‐two infants were listed 1A, 66% with congenital heart disease. Median age and weight at listing were 2.2 months and 4.4 kg, with 69% weighing