Recent progress in biologically active indole hybrids: a mini review

The indole moiety is one of the most widespread heterocycles found in both natural products and biological systems. Indoles have important biological activities including anticancer, antioxidant, anti-inflammatory, antifungal, anticholinesterase, and antibacterial properties. Scientists are therefor...

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Published in:Pharmacological reports 2022-08, Vol.74 (4), p.570-582
Main Authors: Mahmoud, Esraa, Hayallah, Alaa M., Kovacic, Suzana, Abdelhamid, Dalia, Abdel-Aziz, Mohamad
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Language:English
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Drug Safety and Pharmacovigilance
Medicine
Pharmacotherapy
Pharmacy
Review
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description The indole moiety is one of the most widespread heterocycles found in both natural products and biological systems. Indoles have important biological activities including anticancer, antioxidant, anti-inflammatory, antifungal, anticholinesterase, and antibacterial properties. Scientists are therefore interested in the synthesis of biologically active indole-based hybrids such as indole–coumarin, indole–chalcone, indole–isatin, indole–pyrimidine and so on, with the aim of improving activity, selectivity, and mitigating side effects. This review will discuss the newly synthesized indole-based hybrids along with their biological activity which will be useful in drug discovery and development.
doi_str_mv 10.1007/s43440-022-00370-3
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subjects Drug Safety and Pharmacovigilance
Medicine
Pharmacotherapy
Pharmacy
Review
title Recent progress in biologically active indole hybrids: a mini review
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