Identification of miR-195-5p as a novel prognostic biomarker for colorectal cancer

Background Recent evidence indicated that transcription patterns of microRNAs could be used as promising biomarkers for numerous cancers. It is stated that miR-195-5p could be used as a tumor suppressor in colorectal cancer (CRC). The purpose of the current work was to explore the transcription leve...

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Bibliographic Details
Published in:Molecular biology reports 2022-07, Vol.49 (7), p.6453-6457
Main Authors: Bayat, Amir, Raad, Mohammad, Sharafshah, Alireza, Ahmadvand, Mohammad, Aminian, Hesam
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Biomarkers
Biomarkers, Tumor - genetics
Biomedical and Life Sciences
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
Gene Expression Regulation, Neoplastic - genetics
Genes, Tumor Suppressor
Histology
Humans
Life Sciences
Lymph nodes
Lymphatic Metastasis
Metastases
MicroRNAs - metabolism
miRNA
Morphology
Original Article
Patients
Polymerase chain reaction
Prognosis
Transcription
Tumor suppressor genes
Tumors
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Summary:Background Recent evidence indicated that transcription patterns of microRNAs could be used as promising biomarkers for numerous cancers. It is stated that miR-195-5p could be used as a tumor suppressor in colorectal cancer (CRC). The purpose of the current work was to explore the transcription level of miR-195-5p and its clinical relevance in CRC patients. Methods and results We used quantitative real-time polymerase chain reaction (qRT-PCR) to assess the tumor tissue sample of 140 CRC cases compared with normal adjacent tissue for the transcription of miR-195-5p and the clinicopathological relevance was statistically evaluated. We showed that tumor tissue miR-195-5p transcription was statistically downregulated in patients with CRC (median expression value 0.23, range 0.03–6.62) compared to normal adjacent tissue (median expression value 0.98, range 0.092–29.6, p 
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-022-07462-6