A quinoline-coumarin near-infrared ratiometric fluorescent probe for detection of sulfur dioxide derivatives

• Published in: Analytica chimica acta 2022-06, Vol.1211, p.339908-339908, Article 339908
• Main Authors: Liu, Feng-Ting, Li, Na, Chen, Yong-Shun, Yu, Hui-Ying, Miao, Jun-Ying, Zhao, Bao-Xiang
• Format: Article
• Language: English
• Subjects: Cell image; FRET; NIR; Ratiometric fluorescent probe; SO2 derivatives
• ISSN: 0003-2670; 1873-4324
• DOI: 10.1016/j.aca.2022.339908

Sulfur dioxide derivatives (HSO3− and SO32−) play an important role in food preservative, antibacterial, antioxidant and other aspects, so it is urgent for us to develop more efficient detection methods to broaden their application in biochemical research and related disease diagnosis. Fluorescent probes are of particular interest because of their simplicity and high temporal and spatial resolution. Herein, we constructed a new near-infrared (NIR) fluorescence probe, CQC, composed of coumarin fluorophore and quinoline fluorophore, for detecting SO2 derivatives. The near-infrared emission probe CQC with a large Stokes shift (260 nm) not only kept the distance between the two emission peaks large enough (165 nm), but also had a particularly high energy transfer efficiency (99.5%), and was particularly sensitive to the detection of HSO3−/SO32− (LOD: 0.1 μM). The powerful probe CQC succeeded in real-time visualizing endogenous HSO3−/SO32− in living cells. [Display omitted] •A NIR fluorescent probe CQC was designed for detection of SO2 derivatives.•CQC had a large Stokes shift of 260 nm, and 99.5% energy transfer efficiency.•CQC showed high sensitivity and selectivity.•CQC achieved the dual colorimetric and ratiometric fluorescent strategy.•CQC achieved the detection of exogenous and endogenous SO2 derivatives in living cells.