Ajwa date flavonoids mitigate neutrophil migration and interferon-γ-induced renal injury by ultraviolet C radiation in rats

   Date was considered a high nutritional value fruit due to its high content of active ingredients. Frequent exposure to cosmetic radiations including UVC caused deleterious effects and tissue damage and organ affection. This study investigated the efficacy of Ajwa date extract (ADE) in protection...

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Bibliographic Details
Published in:Environmental science and pollution research international 2022-10, Vol.29 (47), p.71607-71613
Main Authors: Abulnaja, Khalid O., Kannan, Kurunthachalam, Al-Manzlawi, Ashgan Mohammed K., Kumosani, Taha A., Qari, Mohamed, Moselhy, Said S.
Format: Article
Language:English
Subjects:
8-Hydroxyguanine
Abnormalities
Antioxidants
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Biochemical markers
Catechol
Damage
DNA damage
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
Exposure
Flavonoids
Glutathione
Ingredients
Injury prevention
Interferon
Kaempferol
Kidneys
Leukocyte migration
Leukocytes (neutrophilic)
Markers
Neutrophils
Nutritive value
Procollagen
Quercetin
Radiation
Radiation dosage
Research Article
Thymine
Ultraviolet radiation
Waste Water Technology
Water Management
Water Pollution Control
γ-Interferon
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Summary:   Date was considered a high nutritional value fruit due to its high content of active ingredients. Frequent exposure to cosmetic radiations including UVC caused deleterious effects and tissue damage and organ affection. This study investigated the efficacy of Ajwa date extract (ADE) in protection against UVC-induced kidney injury in rats. Five groups of rats were included in this study. Group I: Rats were exposed to UVC radiation at a dose 5 kJ (1 h/day) for 28 days. Group II: Rats were pretreated orally with ADE (10 mg/kg/day) 1 h before exposure to UVC radiation with dose 5 kJ. Group III: Rats were pretreated with ADE (15 mg/kg) 1 h before exposure to UVC radiation. Group IV: Rats were exposed to UVC radiation then treated with ADE (10 mg/kg). Group V: Rats exposed to UV radiation then treated with ADE (15 mg/kg) after 1 h from exposure. Analyzing the active constituents of ADE by GC/MS showed that, quercetin, myricetin kaempferol, thymine, and catechol are the most active ingredients. Biochemical markers obtained showed that, serum 8-oxoguanine as marker for DNA damage was increased, and total antioxidant activity and glutathione reduced were decreased ( p  
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-022-20956-x