High seroprotection rates and geometric mean titre increases after repeated annual influenza vaccinations in a cohort of HIV-infected adults in Austria

Vaccination against seasonal influenza is recommended for all HIV-infected persons. Few data have been reported on the effect of repeated annual vaccination in this population. We measured haemagglutination inhibition antibody responses and investigated seroprotection rates in 344 HIV-infected adult...

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Bibliographic Details
Published in:Vaccine 2022-06, Vol.40 (29), p.3948-3953
Main Authors: Kitchen, Maria, Leierer, Gisela, Kistner, Otfried, Wodal, Walter, Gisinger, Martin, Zangerle, Robert, Sarcletti, Mario
Format: Article
Language:English
Subjects:
Adults
Age
Age groups
Antibodies
CD4 antigen
Confidence intervals
Creatinine
Hemagglutination inhibition
HIV
Human immunodeficiency virus
Immune response
Immunogenicity
Influenza
Influenza vaccine
Laboratories
Neopterin
Patients
Public health
Regression analysis
Seroprotection
Vaccination
Vaccines
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Description
Summary:Vaccination against seasonal influenza is recommended for all HIV-infected persons. Few data have been reported on the effect of repeated annual vaccination in this population. We measured haemagglutination inhibition antibody responses and investigated seroprotection rates in 344 HIV-infected adults before and 12 weeks after influenza vaccination with a trivalent subunit vaccine. 68.3% of patients were male, the median age was 45 years. 83.7% had a viral load 
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2022.05.004