Cow's milk α S1 -casein is more sensitizing than goat's milk α S1 -casein in a mouse model

The aim of this study was to compare the sensitization of α -CN in cow and goat's milk in a mouse model. Fifty mice were divided into control group, adjuvant control group, cow's milk α -CN sensitized group, goat's milk α -CN sensitized group and cross sensitized group. Cow's and...

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Bibliographic Details
Published in:Food & function 2022-06, Vol.13 (12), p.6484-6497
Main Authors: Zhang, Kai, Zhang, Lina, Zhou, Ruoya, Zhong, Jinjing, Xie, Kui, Hou, Yanmei, Zhou, Peng
Format: Article
Language:English
Subjects:
Allergenicity
Casein
Cow's milk
Goat's milk
Goats
Helper cells
Immunoglobulin E
Inflammation
Lipopolysaccharides
Lymphocytes T
Milk
NF-κB protein
Sensitizing
TLR4 protein
Toll-like receptors
Transcription factors
γ-Interferon
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Summary:The aim of this study was to compare the sensitization of α -CN in cow and goat's milk in a mouse model. Fifty mice were divided into control group, adjuvant control group, cow's milk α -CN sensitized group, goat's milk α -CN sensitized group and cross sensitized group. Cow's and goat's milk α -CN were used to establish a mouse sensitization model. The results showed that cow's milk α -CN had higher allergenicity than goat's milk α -CN, as can be seen in significantly increased s-IgE and Th2 cell-related inflammatory factors, the proportion of Th2, and the expression of Th2 cell-related transcription factors. Furthermore, the sensitization of cow's milk α -CN damaged the intestinal barrier of mice, caused the leakage of LPS, activated the TLR4-NFκB pathway, and thus resulted in the increase of IFN-γ. In addition, mice allergic to cow's milk α -CN were less sensitized to goat's milk α -CN.
ISSN:2042-6496
2042-650X
DOI:10.1039/D2FO01136K