Acrolein, an environmental toxicant and its applications to in vivo and in vitro atherosclerosis models: An update

Cardiovascular disease, the foremost cause of death worldwide, is an overarching disease term that encompasses a number of disorders involving the heart and circulatory system, including atherosclerosis. Atherosclerosis is a primary cause of cardiovascular diseases and is caused by buildup of plaque...

Full description

Saved in:
Bibliographic Details
Published in:Environmental toxicology and pharmacology 2022-07, Vol.93, p.103890, Article 103890
Main Authors: Crowley, Liana N., Le, Brandy L., Cicalo, Cara, Brown, Justin, Li, Yali, Kim, Young Jun, Lee, Jin Hyup, Pan, Jeong Hoon, Lennon, Shannon L., Han, Bok Kyung, Kim, Jae Kyeom
Format: Article
Language:English
Subjects:
Acrolein
Acrolein - toxicity
Aldehydes
Arteriosclerosis
Atherosclerosis
Atherosclerosis - chemically induced
Blood vessels
Cardiovascular Diseases
Cigarette smoke
Circulatory system
Environmental Pollutants
Environmental toxicant
Epidemiology
Etiology
Hazardous Substances
Humans
In vivo methods and tests
Pollutants
Toxicants
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiovascular disease, the foremost cause of death worldwide, is an overarching disease term that encompasses a number of disorders involving the heart and circulatory system, including atherosclerosis. Atherosclerosis is a primary cause of cardiovascular diseases and is caused by buildup of plaque and narrowing of blood vessels. Epidemiological studies have suggested that environmental pollutants are implicated in atherosclerosis disease progression. Among many environmental pollutants, acrolein (Acr) is an abundant reactive aldehyde and is ubiquitously present in cigarette smoke as well as food products (e.g., overheated oils and wine). Despite its ubiquitous presence and potential impact on the etiology of cardiovascular disease, a limited consensus has been made in regard to Acr exposure conditions to induce atherosclerosis in vivo. This mini-review summarizes in vivo atherosclerosis models using Acr to investigate biochemical and phenotypic changes related to atherosclerosis and in vitro mechanistic studies involving Acr and atherosclerosis.
ISSN:1382-6689
1872-7077
1872-7077
DOI:10.1016/j.etap.2022.103890