Hydrogel Nanoarchitectonics: An Evolving Paradigm for Ultrasensitive Biosensing

The integration of nanoarchitectonics and hydrogel into conventional biosensing platforms offers the opportunities to design physically and chemically controlled and optimized soft structures with superior biocompatibility, better immobilization of biomolecules, and specific and sensitive biosensor...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2022-07, Vol.18 (26), p.e2107571-n/a
Main Authors: Nishat, Zakia Sultana, Hossain, Tanvir, Islam, Md. Nazmul, Phan, Hoang‐Phuong, Wahab, Md A., Moni, Mohammad Ali, Salomon, Carlos, Amin, Mohammed A., Sina, Abu Ali Ibn, Hossain, Md Shahriar A., Kaneti, Yusuf Valentino, Yamauchi, Yusuke, Masud, Mostafa Kamal
Format: Article
Language:English
Subjects:
Biocompatibility
Biomolecules
Biosensors
Chemical properties
Design optimization
Electrical stimuli
hydrogel
Hydrogels
nanoarchitectonic
nanobiotechnology
nanodiagnostics
Nanostructure
Nanotechnology
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Summary:The integration of nanoarchitectonics and hydrogel into conventional biosensing platforms offers the opportunities to design physically and chemically controlled and optimized soft structures with superior biocompatibility, better immobilization of biomolecules, and specific and sensitive biosensor design. The physical and chemical properties of 3D hydrogel structures can be modified by integrating with nanostructures. Such modifications can enhance their responsiveness to mechanical, optical, thermal, magnetic, and electric stimuli, which in turn can enhance the practicality of biosensors in clinical settings. This review describes the synthesis and kinetics of gel networks and exploitation of nanostructure‐integrated hydrogels in biosensing. With an emphasis on different integration strategies of hydrogel with nanostructures, this review highlights the importance of hydrogel nanostructures as one of the most favorable candidates for developing ultrasensitive biosensors. Moreover, hydrogel nanoarchitectonics are also portrayed as a promising candidate for fabricating next‐generation robust biosensors. Hydrogel nanoarchitectonics provide the opportunities to design physically‐ and chemically‐ controlled and optimized soft structures with synergistic properties and unique nanostructures for promoting responsiveness to mechanical, optical, thermal, magnetic, and electrical stimuli, which in turn open avenues for fabricating next‐generation robust biosensors for clinical settings.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202107571