LINC00839 Promotes the Progression of Gastric Cancer by Sponging miR-1236-3p

In this paper, LINC00839 expression in gastric cancer (GC) was confirmed by real-time quantitative PCR. The function of LINC00839 in GC was detected by loss of function assays. Luciferase assays was performed to confirm the interaction between LINC00839 and miR-1236-3p . Then we investigated the reg...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2022-05, Vol.173 (1), p.81-86
Main Authors: An, J. X., Ma, Z. S., Yu, W. J., Xie, B. J., Zhu, F. S., Zhou, Y. X., Cao, F. L.
Format: Article
Language:English
Subjects:
Binding sites
Biomedical and Life Sciences
Biomedicine
Cancer
Cell Biology
Cell growth
Cell Line, Tumor
Cell proliferation
Cell Proliferation - genetics
Development and progression
Gastric cancer
Gene Expression Regulation, Neoplastic - genetics
Humans
Internal Medicine
Laboratory Medicine
Luciferase
Metastasis
MicroRNAs - genetics
MicroRNAs - metabolism
Mutation
Oncology
Pathology
Proteins
Reporter gene
RNA, Long Noncoding - genetics
Stomach cancer
Stomach Neoplasms - genetics
Stomach Neoplasms - metabolism
Tumors
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Summary:In this paper, LINC00839 expression in gastric cancer (GC) was confirmed by real-time quantitative PCR. The function of LINC00839 in GC was detected by loss of function assays. Luciferase assays was performed to confirm the interaction between LINC00839 and miR-1236-3p . Then we investigated the regulatory effect of LINC00839 on miR-1236-3p . The results confirmed that the expression level of LINC00839 in GC was significantly up-regulated. LINC00839 could promote GC cell proliferation, mobility, and invasion. The detection of luciferase reporter gene confirmed that LINC000839 could bind to the binding site of miR-1236-3p . Our findings suggest that LINC00839 promotes GC progression through sponging miR-1236-3p .
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-022-05498-z