Effect of p-Tyrosol on the Process of Left-Ventricular Remodeling in the Long Period after Myocardial Infarction

The effect of p -tyrosol on the main hemodynamic parameters and contractile function of the heart was studied and a morphometric assessment of left-ventricular remodeling was performed in Wistar rats 2 months after acute 1-h myocardial ischemia followed by reperfusion. p -Tyrosol in a dose of 20 mg/...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2022-05, Vol.173 (1), p.17-20
Main Authors: Chernysheva, G. A., Smol’yakova, V. I., Osipenko, A. N., Plotnikova, T. M., Plotnikov, M. B.
Format: Article
Language:English
Subjects:
Analysis
Biomedical and Life Sciences
Biomedicine
Cell Biology
Connective tissues
Heart
Heart attack
Heart attacks
Hemodynamics
Internal Medicine
Ischemia
Laboratory Medicine
Muscle contraction
Myocardial infarction
Myocardial ischemia
Pathology
Reperfusion
Tyrosol
Ventricle
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of p -tyrosol on the main hemodynamic parameters and contractile function of the heart was studied and a morphometric assessment of left-ventricular remodeling was performed in Wistar rats 2 months after acute 1-h myocardial ischemia followed by reperfusion. p -Tyrosol in a dose of 20 mg/kg was injected intraperitoneally 5 times: 20 min before the start of reperfusion, 4 h after the start of reperfusion, and then once a day over the next 3 days. Administration of p -tyrosol to animals in the acute period of myocardial infarction slowed down the formation of systolic and diastolic myocardial dysfunction, improved the pumping function of the heart, maintained the hemodynamic parameters at a significantly higher level, and reduced left-ventricular remodeling in the late period of myocardial infarction. In 2 months after acute myocardial ischemia modeling, the dimensions of the left-ventricular cavity, the area of the postinfarction focus, and the area of connective tissue in rats treated with p -tyrosol were significantly lower than in the control group. In the group treated with p -tyrosol, no anterior left-ventricular wall aneurysms were found.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-022-05483-6